NR1H3

Gene Symbol NR1H3
Entrez Gene 10062
Alt Symbol LXR-a, LXRA, RLD-1
Species Human
Gene Type protein-coding
Description nuclear receptor subfamily 1, group H, member 3
Other Description liver X nuclear receptor alpha variant 1|oxysterols receptor LXR-alpha
Swissprots Q96H87 Q8IW13 D3DQR1 Q13133 A8K3J9
Accessions EAW67942 EAW67943 EAW67944 EAW67945 EAW67946 EAW67947 EAW67948 EAW67949 Q13133 AA644385 AB307698 BAH02289 AI097478 AI648486 AK122661 BAG53649 AK290614 BAF83303 AK302132 BAG63507 AK309027 AK311590 AK313311 BAG36116 AU133574 AU135617 BC008819 AAH08819 BC041172 AAH41172 BM835230 BP300071 BT019411 AAV38218 CV026805 EU831967 ACE87408 EU832060 ACE86722 HQ692819 ADZ17330 U22662 AAA85856 XM_005252705 XP_005252762 XM_005252706 XP_005252763 XM_005252707 XP_005252764 XM_005252709 XP_005252766 XM_005252710 XP_005252767 XM_005252713 XP_005252770 XM_005252715 XP_005252772 XM_005252716 XP_005252773 XM_005252718 XP_005252775 XM_006718112 XP_006718175 XM_006718113 XP_006718176 XM_006718114 XP_006718177 XM_006718115 XP_006718178 XM_006718116 XP_006718179 XM_011519805 XP_011518107 XM_011519806 XP_011518108 XM_011519807 XP_011518109 XM_011519808 XP_011518110 NM_001130101 NP_001123573 NM_001130102 NP_001123574 NM_001251934 NP_001238863 NM_001251935 NP_001238864 NM_005693 NP_005684
Function Nuclear receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand- binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half- sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407}.
Tissue Specificity Visceral organs specific expression. Strong expression was found in liver, kidney and intestine followed by spleen and to a lesser extent the adrenals.
Top Pathways PPAR signaling pathway, Hepatitis C, Non-alcoholic fatty liver disease (NAFLD)

LXRα CRISPR/Cas9 KO Plasmid (h) - sc-417569 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LXRα HDR Plasmid (h) - sc-417569-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LXRα Double Nickase Plasmid (h) - sc-417569-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LXRα Double Nickase Plasmid (h2) - sc-417569-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LXRα CRISPR Activation Plasmid (h) - sc-417569-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LXRα CRISPR Activation Plasmid (h2) - sc-417569-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LXRα Lentiviral Activation Particles (h) - sc-417569-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LXRα Lentiviral Activation Particles (h2) - sc-417569-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LXRα siRNA (h) - sc-38828 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LXRα shRNA Plasmid (h) - sc-38828-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LXRα shRNA (h) Lentiviral Particles - sc-38828-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU134631 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1045 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1045 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

NR1H3 siRNA (Human) - CRH6778 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

LXR alpha/NR1H3 RNAi - H00010062-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

shRNA set against Human NR1H3 (NM_005693.3) - SHH354672 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human NR1H3(NM_001130102.2) - SHR020047 from Creative biogene

Category siRNA
Species Reactivities Human

NR1H3 shRNA Plasmid (Human) - CHH6778 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

NR1H3 miRNA 3'UTR clone - MiUTR1H-06893 from Creative biogene

Species Reactivities Human

NR1H3 miRNA 3'UTR clone - MiUTR3H-04967 from Creative biogene

Species Reactivities Human

NR1H3 miRNA 3'UTR clone - MiUTR3H-04969 from Creative biogene

Species Reactivities Human
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