| Gene Symbol | Ednra |
|---|---|
| Entrez Gene | 24326 |
| Alt Symbol | ET-A, ET-AR, Endor, Eta, RGD1559432 |
| Species | Rat |
| Gene Type | protein-coding |
| Description | endothelin receptor type A |
| Other Description | endothelin A receptor|endothelin-1 receptor |
| Swissprots | P26684 |
| Accessions | EDL92330 P26684 CB798671 DQ832324 ABH10615 DQ839232 ABI33934 DQ839233 ABI33935 DQ839234 ABI33936 M60786 AAA41114 XM_006255420 XP_006255482 XM_008772471 XP_008770693 XM_008772472 XP_008770694 NM_012550 NP_036682 |
| Function | Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Predominantly expressed in vascular smooth muscle cells of a variety of issues, bronchial smooth muscle cells, myocardium, and the pituitary gland. |
| Top Pathways | Calcium signaling pathway, Vascular smooth muscle contraction, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction |