| Gene Symbol |
Ednra
|
| Entrez Gene |
24326
|
| Alt Symbol |
ET-A, ET-AR, Endor, Eta, RGD1559432
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
endothelin receptor type A
|
| Other Description |
endothelin A receptor|endothelin-1 receptor
|
| Swissprots |
P26684
|
| Accessions |
EDL92330 P26684 CB798671 DQ832324 ABH10615 DQ839232 ABI33934 DQ839233 ABI33935 DQ839234 ABI33936 M60786 AAA41114 XM_006255420 XP_006255482 XM_008772471 XP_008770693 XM_008772472 XP_008770694 NM_012550 NP_036682
|
| Function |
Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Predominantly expressed in vascular smooth muscle cells of a variety of issues, bronchial smooth muscle cells, myocardium, and the pituitary gland.
|
| Top Pathways |
Calcium signaling pathway, Vascular smooth muscle contraction, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction
|