| Gene Symbol | ABI1 |
|---|---|
| Entrez Gene | 10006 |
| Alt Symbol | ABI-1, ABLBP4, E3B1, NAP1BP, SSH3BP, SSH3BP1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | abl-interactor 1 |
| Other Description | Abelson interactor 1|Abl-interactor protein 1 long|abl interactor 1|abl-binding protein 4|eps8 SH3 domain-binding protein|interactor protein AblBP4|nap1 binding protein|spectrin SH3 domain-binding protein 1 |
| Swissprots | Q96S81 Q9NYB8 B4DQ58 Q8TB63 A9Z1Y6 H7BXI6 Q9NXZ9 Q8IZP0 O76049 O95060 Q5T2R3 Q5W072 Q5T2R7 B3KX62 Q5T2R6 Q5T2R9 O15147 Q5W070 Q5T2R4 |
| Accessions | CAB88006 CCQ43032 EAW86077 EAW86078 EAW86079 EAW86080 EAW86081 EAW86082 EAW86083 Q8IZP0 AB040151 BAB55675 AB209268 BAD92505 AF001628 AAD00897 AF006516 AAB62569 AF260262 AAF70309 AF540955 AAN28379 AK126803 BAG54374 AK291823 BAF84512 AK296751 BAG59334 AK298646 BAG60820 AK315914 BAH14285 BC013238 BC024254 AAH24254 DB019974 FJ380057 ACJ12783 FJ380058 ACJ12784 FJ380059 ACJ12785 U87166 AAC39757 XM_005252332 XP_005252389 XM_005252333 XP_005252390 XM_006717359 XP_006717422 XM_006717360 XP_006717423 XM_006717361 XP_006717424 XM_011519289 XP_011517591 NM_001012750 NP_001012768 NM_001012751 NP_001012769 NM_001012752 NP_001012770 NM_001178116 NP_001171587 NM_001178119 NP_001171590 NM_001178120 NP_001171591 NM_001178121 NP_001171592 NM_001178122 NP_001171593 NM_001178123 NP_001171594 NM_001178124 NP_001171595 NM_001178125 NP_001171596 NM_005470 NP_005461 |
| Function | May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. {ECO:0000269|PubMed:11003655, ECO:0000269|PubMed:18328268}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Localized to protruding lamellipodia and filopodia tips. Also localized to neuronal growth cones and synaptosomes. May shuttle from the postsynaptic densities to the nucleus (By similarity). {ECO:0000250}. |
| Tissue Specificity | Widely expressed, with highest expression in brain. {ECO:0000269|PubMed:11418237}. |
Abi-1 CRISPR/Cas9 KO Plasmid (h) - sc-417534 from Santa Cruz Biotechnology
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Abi-1 HDR Plasmid (h) - sc-417534-HDR from Santa Cruz Biotechnology
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Abi-1 Double Nickase Plasmid (h) - sc-417534-NIC from Santa Cruz Biotechnology
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Abi-1 Double Nickase Plasmid (h2) - sc-417534-NIC-2 from Santa Cruz Biotechnology
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Abi-1 CRISPR Activation Plasmid (h) - sc-417534-ACT from Santa Cruz Biotechnology
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Abi-1 CRISPR Activation Plasmid (h2) - sc-417534-ACT-2 from Santa Cruz Biotechnology
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Abi-1 Lentiviral Activation Particles (h) - sc-417534-LAC from Santa Cruz Biotechnology
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Abi-1 Lentiviral Activation Particles (h2) - sc-417534-LAC-2 from Santa Cruz Biotechnology
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Abi-1 siRNA (h) - sc-40306 from Santa Cruz Biotechnology
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Abi-1 shRNA Plasmid (h) - sc-40306-SH from Santa Cruz Biotechnology
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Abi-1 shRNA (h) Lentiviral Particles - sc-40306-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU059521 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2669 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2669 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12835 from Sigma-Aldrich
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ABI1 siRNA (Human) - CRH6734 from Cohesion Biosciences
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ABI1 - MBS827403 from MyBioSource
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shRNA set against Human ABI1 (NM_005470.3) - SHH229574 from Creative biogene
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Human ABI1 siRNA - orb267236 from Biorbyt
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ABI1 shRNA Plasmid (Human) - CHH6734 from Cohesion Biosciences
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ABI1 miRNA 3'UTR clone - MiUTR1H-00068 from Creative biogene
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ABI1 miRNA 3'UTR clone - MiUTR1H-00069 from Creative biogene
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ABI1 miRNA 3'UTR clone - MiUTR1H-00070 from Creative biogene
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ABI1 miRNA 3'UTR clone - MiUTR1H-00071 from Creative biogene
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ABI1 miRNA 3'UTR clone - MiUTR1H-00072 from Creative biogene
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