BBS2

Gene Symbol	BBS2
Entrez Gene	583
Alt Symbol	BBS
Species	Human
Gene Type	protein-coding
Description	Bardet-Biedl syndrome 2
Other Description	Bardet-Biedl syndrome 2 protein
Swissprots	Q96SN9 Q96CM0 Q9BXC9
Accessions	EAW82863 EAW82864 Q9BXC9 AB208905 BAD92142 AF342736 AAK28552 AK027635 BAB55252 AK127290 AK289604 BAF82293 AK309068 AL834176 CAD38873 BC014140 AAH14140 BM982214 DA437930 DB316257 DQ892680 ABM83606 DQ895923 ABM86849 XM_005256080 XP_005256137 XM_005256081 XP_005256138 XM_005256082 XP_005256139 XM_011523251 XP_011521553 XR_933378 XR_933379 XR_933380 NM_031885 NP_114091
Function	The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization. {ECO:0000269|PubMed:17574030, ECO:0000269|PubMed:22072986}.
Subcellular Location	Cell projection, cilium membrane. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite.
Tissue Specificity	Widely expressed.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human BBS2 full length protein - ab157956 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

BBS2 / BBS Antibody Blocking Peptide - LS-E21868 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BBS2 / BBS Antibody Blocking Peptide - LS-E21869 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human BBS2 Protein - H00000583-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

BBS2 Blocking Peptide - 33R-7948 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

BBS2 Blocking Peptide - 33R-3554 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

BBS2 - H00000583-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

BBS2 - H00000583-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

BBS2 fusion protein - ag1662 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

BBS2 fusion protein - ag21390 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human Bardet-Biedl syndrome 2 protein(BBS2) - CSB-YP866303HU CSB-EP866303HU CSB-BP866303HU CSB-MP866303HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

BBS2 Protein - abx163886 from Abbexa Category Protein Species Human

BBS2 Recombinant Protein Antigen - NBP1-91695PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

BBS2 Peptide, Human - M34GP01343H from Creative Peptides Category Peptide Source Synthetic. Species Human

BBS2 Antibody - SH-A10552 from Novatein Biosciences Prices $315.00 Sizes 100 µl Species Human, Mouse, Rat

Bardet-Biedl syndrome 2 protein (BBS2), Recombinant Protein - MBS1346020 from MyBioSource Category Protein Prices $1,530.00, $1,530.00, $1,760.00, $1,760.00, $2,625.00, $2,625.00, $3,070.00, $3,070.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Recombinant Human BBS2 Protein, GST-tagged - BBS2-107H from Creative Biomart Category Protein Source Wheat Germ Species Human

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