| Gene Symbol | PDPK1 |
|---|---|
| Entrez Gene | 5170 |
| Alt Symbol | PDK1, PDPK2, PDPK2P, PRO0461 |
| Species | Human |
| Gene Type | protein-coding |
| Description | 3-phosphoinositide dependent protein kinase 1 |
| Other Description | 3-phosphoinositide dependent protein kinase-1|3-phosphoinositide-dependent protein kinase 1|3-phosphoinositide-dependent protein kinase 2 pseudogene|PkB kinase like gene 1 |
| Swissprots | Q6FI20 Q8IV52 Q9BRD5 Q59EH6 H0Y4Z0 O15530 |
| Accessions | AAC33797 CAC10873 EAW85495 O15530 Q6A1A2 AB209835 BAD93072 AF017995 AAC51825 AF111845 AAF16685 AJ785968 CAH05056 AK095507 AK131060 AK222581 BAD96301 AK293900 BAG57287 AL157446 BC000789 BC006339 AAH06339 BC012103 AAH12103 BC012540 BC033494 AAH33494 BC040324 BI830733 CR536517 CAG38755 DQ892297 ABM83223 DQ895496 ABM86422 EU832784 ACE87795 GQ129441 ACT64575 Y15056 CAA75341 XM_005255356 XP_005255413 XM_011522521 XP_011520823 XM_011522522 XP_011520824 XM_011522523 XP_011520825 XM_011522524 XP_011520826 NM_001261816 NP_001248745 NM_002613 NP_002604 NM_031268 NP_112558 |
| Function | Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases. Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), protein kinase PKN (PKN1 and PKN2). Plays a central role in the transduction of signals from insulin by providing the activating phosphorylation to PKB/AKT1, thus propagating the signal to downstream targets controlling cell proliferation and survival, as well as glucose and amino acid uptake and storage. Negatively regulates the TGF-beta-induced signaling by: modulating the association of SMAD3 and SMAD7 with TGF-beta receptor, phosphorylating SMAD2, SMAD3, SMAD4 and SMAD7, preventing the nuclear translo |
| Subcellular Location | Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Cell junction, focal adhesion. Note=Tyrosine phosphorylation seems to occur only at the cell membrane. Translocates to the cell membrane following insulin stimulation by a mechanism that involves binding to GRB14 and INSR. SRC and HSP90 promote its localization to the cell membrane. Its nuclear localization is dependent on its association with PTPN6 and its phosphorylation at Ser-396. Restricted to the nucleus in neuronal cells while in non-neuronal cells it is found in the cytoplasm. The Ser-241 phosphorylated form is distributed along the perinuclear region in neuronal cells while in non- neuronal cells it is found in both the nucleus and the cytoplasm. IGF1 transiently increases phosphorylation at Ser-241 of neuronal PDPK1, resulting in its translocation to other cellular compartments. The tyrosine-phosphorylated form colocalizes with PTK2B in focal adhesions after angiotensin II stimulation. |
| Tissue Specificity | Appears to be expressed ubiquitously. The Tyr- 9 phosphorylated form is markedly increased in diseased tissue compared with normal tissue from lung, liver, colon and breast. {ECO:0000269|PubMed:18024423}. |
| Top Pathways | Proteoglycans in cancer, AMPK signaling pathway, PI3K-Akt signaling pathway, Choline metabolism in cancer, Sphingolipid signaling pathway |