PDPK1

Gene Symbol	PDPK1
Entrez Gene	5170
Alt Symbol	PDK1, PDPK2, PDPK2P, PRO0461
Species	Human
Gene Type	protein-coding
Description	3-phosphoinositide dependent protein kinase 1
Other Description	3-phosphoinositide dependent protein kinase-1|3-phosphoinositide-dependent protein kinase 1|3-phosphoinositide-dependent protein kinase 2 pseudogene|PkB kinase like gene 1
Swissprots	Q6FI20 Q8IV52 Q9BRD5 Q59EH6 H0Y4Z0 O15530
Accessions	AAC33797 CAC10873 EAW85495 O15530 Q6A1A2 AB209835 BAD93072 AF017995 AAC51825 AF111845 AAF16685 AJ785968 CAH05056 AK095507 AK131060 AK222581 BAD96301 AK293900 BAG57287 AL157446 BC000789 BC006339 AAH06339 BC012103 AAH12103 BC012540 BC033494 AAH33494 BC040324 BI830733 CR536517 CAG38755 DQ892297 ABM83223 DQ895496 ABM86422 EU832784 ACE87795 GQ129441 ACT64575 Y15056 CAA75341 XM_005255356 XP_005255413 XM_011522521 XP_011520823 XM_011522522 XP_011520824 XM_011522523 XP_011520825 XM_011522524 XP_011520826 NM_001261816 NP_001248745 NM_002613 NP_002604 NM_031268 NP_112558
Function	Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases. Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), protein kinase PKN (PKN1 and PKN2). Plays a central role in the transduction of signals from insulin by providing the activating phosphorylation to PKB/AKT1, thus propagating the signal to downstream targets controlling cell proliferation and survival, as well as glucose and amino acid uptake and storage. Negatively regulates the TGF-beta-induced signaling by: modulating the association of SMAD3 and SMAD7 with TGF-beta receptor, phosphorylating SMAD2, SMAD3, SMAD4 and SMAD7, preventing the nuclear translo
Subcellular Location	Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Cell junction, focal adhesion. Note=Tyrosine phosphorylation seems to occur only at the cell membrane. Translocates to the cell membrane following insulin stimulation by a mechanism that involves binding to GRB14 and INSR. SRC and HSP90 promote its localization to the cell membrane. Its nuclear localization is dependent on its association with PTPN6 and its phosphorylation at Ser-396. Restricted to the nucleus in neuronal cells while in non-neuronal cells it is found in the cytoplasm. The Ser-241 phosphorylated form is distributed along the perinuclear region in neuronal cells while in non- neuronal cells it is found in both the nucleus and the cytoplasm. IGF1 transiently increases phosphorylation at Ser-241 of neuronal PDPK1, resulting in its translocation to other cellular compartments. The tyrosine-phosphorylated form colocalizes with PTK2B in focal adhesions after angiotensin II stimulation.
Tissue Specificity	Appears to be expressed ubiquitously. The Tyr- 9 phosphorylated form is markedly increased in diseased tissue compared with normal tissue from lung, liver, colon and breast. {ECO:0000269|PubMed:18024423}.
Top Pathways	Proteoglycans in cancer, AMPK signaling pathway, PI3K-Akt signaling pathway, Choline metabolism in cancer, Sphingolipid signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PDPK1 full length protein - ab60834 from Abcam Category Protein Prices $294.00, $1,845.00 Sizes 10 µg, 100 µg Source Baculovirus infected sf9 cells Species Human

Active human PDPK1 full length protein - ab80411 from Abcam Category Protein Prices $343.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human PDPK1 (phospho T513) peptide - ab13755 from Abcam Category Peptide

Human PDPK1 (unmodified ) peptide - ab13756 from Abcam Category Peptide

Human PDPK1 full length protein - ab152602 from Abcam Category Protein Source Wheat germ Species Human

Human PDPK1 protein fragment - ab152603 from Abcam Category Protein Source Wheat germ Species Human

Human PDPK2 protein fragment - ab166584 from Abcam Category Protein Source Wheat germ Species Human

PDK1 Antibody Blocking Peptide - LS-E11090 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PDK1 Antibody Blocking Peptide - LS-E25978 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PDK1 Antibody Blocking Peptide - LS-E8629 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PDPK1 / PDK1 Antibody Blocking Peptide - LS-E10557 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PDPK1 / PDK1 Antibody Blocking Peptide - LS-E7385 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PDK-1 Blocking Peptide - NB100-2383PEP from Novus Biologicals Category Peptide Prices $69.00 Sizes 50 µg Species Human

PDK-1 Peptide - NB100-2384PEP from Novus Biologicals Category Peptide Prices $99.00 Sizes 50 µg

PDPK1 Recombinant Protein - H00005170-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

PDK-1 Partial Recombinant Protein - H00005163-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

PDPK1 Partial Recombinant Protein - H00005170-Q01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

Recombinant Human PDK-1 Protein - NBC1-22919 from Novus Biologicals Category Protein Prices $229.00 Sizes 100 µg Species Human

PDPK2 Partial Protein - H00653650-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PDK-1 Recombinant Protein - P4190 from Novus Biologicals Category Protein Prices $549.00 Sizes 5 µg Species Human

PDPK1 Recombinant Protein - P3891 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 5 µg Species Human

PDPK1 Recombinant Protein - P4750 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

Recombinant PDK-1 Protein - NBP1-99460 from Novus Biologicals Category Protein Prices $295.00 Sizes 5 µg Source Baculovirus (Sf9 insect cells)

PDPK1 Peptide - P2137 from Novus Biologicals Category Peptide Species Human

PDPK1 Peptide - P2136 from Novus Biologicals Category Peptide Species Human

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