| Gene Symbol | Sorbs1 |
|---|---|
| Entrez Gene | 20411 |
| Alt Symbol | 2310065E01Rik, 9530001P15Rik, CAP, SH3P12, Sh3d5, mKIAA1296 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | sorbin and SH3 domain containing 1 |
| Other Description | SH3 domain protein 5|c-Cbl-associated protein|ponsin|sorbin and SH3 domain-containing protein 1|sorbs1 |
| Swissprots | Q8BZI3 Q921F8 Q8K3Y2 Q9Z0Z8 Q80TF8 Q9Z0Z9 Q62417 |
| Accessions | EDL41833 EDL41834 EDL41835 EDL41836 Q62417 AF078666 AAD16007 AF078667 AAD16008 AF521593 AAM77354 AK010043 AK035212 BAC28980 AK043387 AK048504 AK087553 AK122487 BAC65769 AK146712 AK160958 BAE36114 AK166943 AK177559 AK178350 AK178768 AK178866 AK184742 AK185919 AK186618 AK186634 AK187589 AK189270 AK191526 AK191914 AK192916 AK193832 AK195360 AK198654 AK204447 AK205855 AK207719 AK208107 AK209280 AK210392 AK211302 AK212392 AK216023 AK216997 AK217459 AK217829 AK218530 AK218601 BC012703 AAH12703 BY031726 BY273421 U58883 AAC71776 XM_006526789 XP_006526852 XM_006526790 XP_006526853 XM_006526792 XP_006526855 XM_006526793 XP_006526856 XM_006526795 XP_006526858 XM_006526796 XP_006526859 XM_006526798 XP_006526861 XM_006526799 XP_006526862 XM_006526800 XP_006526863 XM_006526801 XP_006526864 XM_006526802 XP_006526865 XM_006526803 XP_006526866 XM_006526804 XP_006526867 XM_006526805 XP_006526868 XM_006526806 XP_006526869 XM_006526807 XP_006526870 XM_006526809 XP_006526872 XM_006526810 XP_006526873 XM_006526813 XP_006526876 XM_011247172 XP_011245474 XM_011247173 XP_011245475 XM_011247174 XP_011245476 XM_011247175 XP_011245477 XM_011247176 XP_011245478 XM_011247177 XP_011245479 XM_011247178 XP_011245480 XM_011247179 XP_011245481 XM_011247180 XP_011245482 XM_011247181 XP_011245483 XM_011247182 XP_011245484 XM_011247183 XP_011245485 XM_011247184 XP_011245486 XM_011247185 XP_011245487 XM_011247186 XP_011245488 XM_011247187 XP_011245489 XM_011247188 XP_011245490 XM_011247189 XP_011245491 XM_011247190 XP_011245492 XM_011247191 XP_011245493 XM_011247192 XP_011245494 XM_011247193 XP_011245495 XM_011247194 XP_011245496 XM_011247195 XP_011245497 XM_011247196 XP_011245498 XM_011247197 XP_011245499 XM_011247198 XP_011245500 XM_011247199 XP_011245501 NM_001034962 NP_001030134 NM_001034963 NP_001030135 NM_001034964 NP_001030136 NM_009166 NP_033192 NM_178362 NP_848139 |
| Function | Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin- stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions. {ECO:0000269|PubMed:11001060, ECO:0000269|PubMed:9447983, ECO:0000269|PubMed:9461600}. |
| Subcellular Location | Cell junction, adherens junction. Cell membrane. Cytoplasm, cytoskeleton. Cell junction, focal adhesion {ECO:0000250}. Nucleus. Nucleus matrix. Note=Colocalized with PXN at focal adhesions during myogenic differentiation (By similarity). Colocalizes with actin stress fibers. Also detected at the plasma membrane and in neuronal intranuclear inclusions. Colocalizes with the Ten-1 ICD form of TENM1 in the nucleus. {ECO:0000250}. |
| Tissue Specificity | Expressed in all tissues tested: heart, brain, spleen, lung, liver, muscle, kidney and testis. Expressed in 3T3- L1 adipocytes but not in 3T3-L1 fibroblasts. {ECO:0000269|PubMed:10085297, ECO:0000269|PubMed:9447983}. |
| Top Pathways | Adherens junction, Insulin signaling pathway, PPAR signaling pathway |
CAP CRISPR/Cas9 KO Plasmid (m) - sc-422919 from Santa Cruz Biotechnology
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CAP HDR Plasmid (m) - sc-422919-HDR from Santa Cruz Biotechnology
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CAP Double Nickase Plasmid (m) - sc-422919-NIC from Santa Cruz Biotechnology
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CAP Double Nickase Plasmid (m2) - sc-422919-NIC-2 from Santa Cruz Biotechnology
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CAP CRISPR Activation Plasmid (m) - sc-422919-ACT from Santa Cruz Biotechnology
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CAP CRISPR Activation Plasmid (m2) - sc-422919-ACT-2 from Santa Cruz Biotechnology
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CAP Lentiviral Activation Particles (m) - sc-422919-LAC from Santa Cruz Biotechnology
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CAP Lentiviral Activation Particles (m2) - sc-422919-LAC-2 from Santa Cruz Biotechnology
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CAP siRNA (m) - sc-40340 from Santa Cruz Biotechnology
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CAP shRNA Plasmid (m) - sc-40340-SH from Santa Cruz Biotechnology
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CAP shRNA (m) Lentiviral Particles - sc-40340-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU187251 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN41815 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND41815 from Sigma-Aldrich
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SORBS1 siRNA (Mouse) - CRM3701 from Cohesion Biosciences
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SORBS1 - MBS8203722 from MyBioSource
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shRNA set against Mouse Sorbs1 (NM_009166.3) - SHH415108 from Creative biogene
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shRNA set against Mouse Sorbs1(NM_001034962.1) - SHL016338 from Creative biogene
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shRNA set against Mouse Sorbs1(NM_001034963.1) - SHL016410 from Creative biogene
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shRNA set against Mouse Sorbs1(NM_001034964.1) - SHL024834 from Creative biogene
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SORBS1 shRNA Plasmid (Mouse) - CHM3701 from Cohesion Biosciences
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SORBS1 miRNA 3'UTR clone - MiUTR1M-11086 from Creative biogene
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SORBS1 miRNA 3'UTR clone - MiUTR1M-11087 from Creative biogene
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SORBS1 miRNA 3'UTR clone - MiUTR1M-11088 from Creative biogene
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SORBS1 miRNA 3'UTR clone - MiUTR1M-11089 from Creative biogene
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