| Gene Symbol | CUX1 |
|---|---|
| Entrez Gene | 1523 |
| Alt Symbol | CASP, CDP, CDP/Cut, CDP1, COY1, CUTL1, CUX, Clox, Cux/CDP, GOLIM6, Nbla10317, p100, p110, p200, p75 |
| Species | Human |
| Gene Type | protein-coding |
| Description | cut-like homeobox 1 |
| Other Description | CCAAT displacement protein|cut homolog|golgi integral membrane protein 6|homeobox protein cux-1|protein CASP|putative protein product of Nbla10317 |
| Swissprots | Q86UJ7 J3KPQ6 G3V1Z6 Q75MT2 B3KV79 Q9UEV5 B3KWH3 J3KQV9 P39880 B4DZZ2 Q75LE5 Q53GU9 Q8TBS3 Q13948 Q6NYH4 B3KWH8 Q75MT3 |
| Accessions | AAC78778 AAP22331 AAS07388 AAS07406 AAS07410 AAS07523 EAW50227 EAW50228 P39880 Q13948 AB075522 BAE45765 AK056307 AK122726 BAG53691 AK125097 BAG54140 AK222832 BAD96552 AK297548 BAG59942 AK303151 BAG64254 BC007204 BC012323 BC025422 AAH25422 BC040199 BC045562 BC066592 AAH66592 DC410774 L12579 AAA35654 M74099 XM_005250150 XP_005250207 XM_005250151 XP_005250208 XM_005250154 XP_005250211 XM_006715854 XP_006715917 XM_006715855 XP_006715918 XM_006715856 XP_006715919 XM_011515823 XP_011514125 XM_011515824 XP_011514126 XM_011515825 XP_011514127 NM_001202543 NP_001189472 NM_001202544 NP_001189473 NM_001202545 NP_001189474 NM_001202546 NP_001189475 NM_001913 NP_001904 NM_181500 NP_852477 NM_181552 NP_853530 |
| Function | Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus. |