Gene Symbol |
Adipor1
|
Entrez Gene |
72674
|
Alt Symbol |
2810031L11Rik, ACDCR1, CGI-45, Paqr1
|
Species |
Mouse
|
Gene Type |
protein-coding
|
Description |
adiponectin receptor 1
|
Other Description |
adiponectin receptor protein 1|progestin and adipoQ receptor family member I
|
Swissprots |
Q91VH1 Q9CZA0
|
Accessions |
CBJ06652 EDL39610 EDL39611 Q91VH1 AK012847 BAB28509 AK137258 AK143679 BAE25492 AK143680 BAE25493 AK148140 BAE28369 AK151565 BAE30507 AK165370 AK167896 BAE39907 AK168069 BAE40044 AK177510 AK177948 AK178204 AK180261 AK180314 AK181422 AK182949 AK183934 AK185902 AK186237 AK186450 AK187788 AK187921 AK188561 AK188694 AK188759 AK189666 AK191648 AK193755 AK200337 AK200997 AK201112 AK204573 AK206006 AK207488 AK208698 AK208958 AK208980 AK209223 AK214372 AK215425 AK217308 AW047193 AY424290 AAR08378 BC014875 AAH14875 BE289695 BI110414 CA945374 CK623806 XM_006529888 XP_006529951 NM_001306069 NP_001292998 NM_028320 NP_082596
|
Function |
Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some high-affinity receptor for globular adiponectin but low-affinity receptor for full-length adiponectin. {ECO:0000269|PubMed:12802337}.
|
Subcellular Location |
Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Localized to the cell membrane and intracellular organelles. {ECO:0000250}.
|
Tissue Specificity |
Widely expressed. Expressed in heart, kidney, liver, lung, skeletal muscle and spleen. Weakly expressed in brain and testis. {ECO:0000269|PubMed:12802337}.
|
Top Pathways |
Adipocytokine signaling pathway, Non-alcoholic fatty liver disease (NAFLD), AMPK signaling pathway
|