| Gene Symbol |
SESTD1
|
| Entrez Gene |
91404
|
| Alt Symbol |
SOLO
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SEC14 and spectrin domains 1
|
| Other Description |
SEC14 domain and spectrin repeat-containing protein 1|huntingtin-interacting protein-like protein|protein Solo
|
| Swissprots |
Q53R38 Q96LQ2 Q53SP3 Q8N6M1 Q5GM69 Q86VW0
|
| Accessions |
AAY24093 AAY24323 CAD10189 EAX11010 Q86VW0 AK056075 AK057944 BAB71618 AK096232 BAG53235 AL122046 CAB59182 AY209190 AAP47744 BC029744 AAH29744 BC047578 AAH47578 BC053862 AAH53862 BC061918 EU832125 ACE87475 EU832219 ACE86789 XM_011512139 XP_011510441 XM_011512140 XP_011510442 XM_011512141 XP_011510443 XR_923061 NM_178123 NP_835224
|
| Function |
May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates, phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent. Might be involved in the plasma membrane localization of CTNNB1. {ECO:0000269|PubMed:20164195}.
|
| Tissue Specificity |
Broad expression. High expression in thalamus and brain. Significantly expressed in vasculature. {ECO:0000269|PubMed:20164195}.
|