CD101
| Gene Symbol | CD101 |
|---|---|
| Entrez Gene | 9398 |
| Alt Symbol | EWI-101, IGSF2, V7 |
| Species | Human |
| Gene Type | protein-coding |
| Description | CD101 molecule |
| Other Description | cell surface glycoprotein V7|glu-Trp-Ile EWI motif-containing protein 101|immunoglobulin superfamily member 2|leukocyte surface protein |
| Swissprots | Q93033 Q15856 |
| Accessions | EAW56664 EAW56665 Q93033 AI791963 AK298237 BAG60504 AK307542 BC130327 AAI30328 BC136484 AAI36485 BC171768 AAI71768 BP300139 DA582363 DA955029 Z33642 CAA83923 XR_946802 NM_001256106 NP_001243035 NM_001256109 NP_001243038 NM_001256111 NP_001243040 NM_004258 NP_004249 |
| Function | Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3- induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4(+) CD56(+) leukemic tumor cells. {ECO:0000269|PubMed:11093127, ECO:0000269|PubMed:15737213, ECO:0000269|PubMed:7722299, ECO:0000269|PubMed:9233604, ECO:0000269|PubMed:9389317, ECO:0000269|PubMed:9647226}. |
| Subcellular Location | Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
| Tissue Specificity | Expressed in lung, thymus and small intestine. Detected in cutaneous dendritic cells, activated T-cells, monocytes and granulocytes as well as with epithelial cells with dendritic morphology. Expressed in some leukemic cells, the CD4(+) CD56(+) blastic tumor cells, as well as in Langerhans cells from LCH (Langerhans cell histiocytosis) patients. {ECO:0000269|PubMed:10692025, ECO:0000269|PubMed:15737213, ECO:0000269|PubMed:7722299, ECO:0000269|PubMed:7722300, ECO:0000269|PubMed:9389317}. |
Human CD101 protein fragment - ab160469 from Abcam
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Recombinant Human IGSF2/CD101 Protein - H00009398-Q01 from Novus Biologicals
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CD101 Blocking Peptide - abx161324 from Abbexa
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CD101 - H00009398-Q01-10 from Acris Antibodies
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CD101 - H00009398-Q01-25 from Acris Antibodies
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IGSF2 fusion protein - Ag23297 from Proteintech Group
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Recombinant Immunoglobulin Superfamily, Member 2 (IGSF2) - RPB432Hu01 from Uscn Life Science Inc.
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Recombinant Immunoglobulin Superfamily, Member 2 (IGSF2) - RPB432Mu01 from Uscn Life Science Inc.
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CD101 Blocking Peptide - CBP3823 from Cohesion Biosciences
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Recombinant Immunoglobulin Superfamily, Member 2 (IGSF2) - RPB432Hu01 from Cloud-clone
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Recombinant Human Immunoglobulin superfamily member 2(CD101) ,partial - CSB-YP842351HU CSB-EP842351HU CSB-BP842351HU CSB-MP842351HU from Cusabio
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IGSF2/CD101 Protein - NBP2-31687PEP from Novus Biologicals
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CD101 Peptide, Human - M34GP02696H from Creative Peptides
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CD101 Recombinant Protein (OPCD04207) - OPCD04207 from Aviva Systems Biology
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Immunoglobulin superfamily member 2 (CD101), partial, Recombinant Protein - MBS1450361 from MyBioSource
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