| Gene Symbol |
OCLN
|
| Entrez Gene |
100506658
|
| Alt Symbol |
BLCPMG, PPP1R115
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
occludin
|
| Other Description |
phosphatase 1, regulatory subunit 115|tight junction protein occludin
|
| Swissprots |
E2CYV9 D2DU64 Q5U1V4 D2IGC0 B5BU70 Q16625 D2DU65 Q8N6K1 D2IGC1
|
| Accessions |
AAL47094 EAW51275 EAW51276 Q16625 AB451306 BAG70120 AB451437 BAG70251 AI093221 AK290697 BAF83386 AK311037 AK313501 BC029886 AAH29886 BK001650 DAA01837 DB226845 DQ786240 DQ892423 ABM83349 DQ895637 ABM86563 FJ786083 ACT53743 FJ786084 ACT53744 GQ225096 ACT83431 GQ225097 ACT83432 GQ225098 ACT83433 GQ402517 ACZ80515 U49184 AAC50451 U53823 AAB00195 NM_001205254 NP_001192183 NM_001205255 NP_001192184 NM_002538 NP_002529
|
| Function |
May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. {ECO:0000269|PubMed:19114660}.
|
| Subcellular Location |
Membrane; Multi-pass membrane protein. Cell junction, tight junction.
|
| Tissue Specificity |
Localized at tight junctions of both epithelial and endothelial cells. Highly expressed in kidney. Not detected in testis.
|
| Top Pathways |
Tight junction, Leukocyte transendothelial migration, Cell adhesion molecules (CAMs), Pathogenic Escherichia coli infection, Hepatitis C
|