| Gene Symbol |
SAT1
|
| Entrez Gene |
6303
|
| Alt Symbol |
DC21, KFSD, KFSDX, SAT, SSAT, SSAT-1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
spermidine/spermine N1-acetyltransferase 1
|
| Other Description |
diamine N-acetyltransferase 1|diamine acetyltransferase 1|polyamine N-acetyltransferase 1|putrescine acetyltransferase|spermidine/spermine N1-acetyltransferase alpha
|
| Swissprots |
P21673
|
| Accessions |
AAA98854 CAA78509 EAW98999 EAW99000 P21673 AF251292 AAG44592 AK310078 AK310094 AK312162 BAG35096 AK315888 BAF98779 AL050290 AW874291 AY841998 AAW03315 BC002503 AAH02503 BC008424 AAH08424 BR000410 FAA00324 BT006825 AAP35471 CD516700 CD638929 CN271682 CR450294 CAG29290 M55580 AAA63260 M77693 AAA60573 NM_002970 NP_002961 NR_027783
|
| Function |
Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)-acetylspermidine and N(8)-acetylspermidine.
|
| Subcellular Location |
Cytoplasm.
|
| Top Pathways |
Arginine and proline metabolism
|