| Gene Symbol |
SHBG
|
| Entrez Gene |
6462
|
| Alt Symbol |
ABP, SBP, TEBG
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sex hormone-binding globulin
|
| Other Description |
sex steroid-binding protein|testis-specific androgen-binding protein|testosterone-binding beta-globulin|testosterone-estradiol-binding globulin|testosterone-estrogen-binding globulin
|
| Swissprots |
P04278 Q3MIL0 Q16616 B0FWH4 I3L1N7 Q6ISD2 F5H5Z8 E9PGW1 P14689
|
| Accessions |
AAC18778 CAA34398 CAA34399 EAW90149 EAW90150 P04278 AK302603 BAG63852 BC069597 AAH69597 BC101785 AAI01786 BC112186 AAI12187 CD013955 CD013957 CD013958 EU352656 ABY68003 EU352657 EU352658 EU352659 ABY67997 EU352660 ABY67998 EU352661 ABY67999 EU352662 ABY68000 EU352663 ABY68001 EU352664 ABY68002 EU352665 ABY68004 EU352666 ABY68005 EU352667 ABY68006 EU352668 ABY68007 EU352669 ABY68008 EU352670 EU352671 EU352672 EU352673 EU352674 EU352675 EU352676 X05403 CAA28987 X05792 CAA29234 X05885 CAA29309 X16351 CAA34400 XM_011523991 XP_011522293 NM_001040 NP_001031 NM_001146279 NP_001139751 NM_001146280 NP_001139752 NM_001146281 NP_001139753 NM_001289113 NP_001276042 NM_001289114 NP_001276043 NM_001289115 NP_001276044 NM_001289116 NP_001276045
|
| Function |
Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.
|
| Subcellular Location |
Secreted {ECO:0000250}. Note=In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis. {ECO:0000250}.
|
| Tissue Specificity |
Isoform 1 and isoform 2 are present in liver and testis.
|