Gene Symbol | ALDH5A1 |
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Entrez Gene | 7915 |
Alt Symbol | SSADH, SSDH |
Species | Human |
Gene Type | protein-coding |
Description | aldehyde dehydrogenase 5 family, member A1 |
Other Description | NAD(+)-dependent succinic semialdehyde dehydrogenase|aldehyde dehydrogenase 5 family member A1|mitochondrial succinate semialdehyde dehydrogenase|succinate-semialdehyde dehydrogenase, mitochondrial |
Swissprots | G5E949 Q8N3W6 B2RD26 Q546H9 P51649 |
Accessions | EAW55452 EAW55453 EAW55454 P51649 AJ427353 CAD20882 AJ427354 CAD20883 AJ427355 CAD20884 AK025722 AK290800 BAF83489 AK294699 BAG57857 AK314357 AK315380 BAG37773 BC034321 AAH34321 DQ891671 ABM82597 DQ894857 ABM85783 KJ534766 AHW56406 KJ534767 AHW56407 KJ534768 AHW56408 KJ534769 AHW56409 L34820 AAA67057 Y11192 CAA72076 NM_001080 NP_001071 NM_170740 NP_733936 |
Function | Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). {ECO:0000269|PubMed:19300440}. |
Subcellular Location | Mitochondrion. |
Tissue Specificity | Brain, pancreas, heart, liver, skeletal muscle and kidney. Lower in placenta. |
Top Pathways | Alanine, aspartate and glutamate metabolism, Butanoate metabolism |
ALDH5A1 CRISPR/Cas9 KO Plasmid (h) - sc-406757 from Santa Cruz Biotechnology
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ALDH5A1 HDR Plasmid (h) - sc-406757-HDR from Santa Cruz Biotechnology
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ALDH5A1 Double Nickase Plasmid (h) - sc-406757-NIC from Santa Cruz Biotechnology
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ALDH5A1 Double Nickase Plasmid (h2) - sc-406757-NIC-2 from Santa Cruz Biotechnology
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ALDH5A1 CRISPR Activation Plasmid (h) - sc-406757-ACT from Santa Cruz Biotechnology
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ALDH5A1 CRISPR Activation Plasmid (h2) - sc-406757-ACT-2 from Santa Cruz Biotechnology
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ALDH5A1 Lentiviral Activation Particles (h) - sc-406757-LAC from Santa Cruz Biotechnology
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ALDH5A1 Lentiviral Activation Particles (h2) - sc-406757-LAC-2 from Santa Cruz Biotechnology
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ALDH5A1 siRNA (h) - sc-72480 from Santa Cruz Biotechnology
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ALDH5A1 shRNA Plasmid (h) - sc-72480-SH from Santa Cruz Biotechnology
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ALDH5A1 shRNA (h) Lentiviral Particles - sc-72480-V from Santa Cruz Biotechnology
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ALDH5A1 RNAi - H00007915-R02 from Novus Biologicals
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ALDH5A1 RNAi - H00007915-R01 from Novus Biologicals
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MISSION® esiRNA - EHU079641 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2551 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2551 from Sigma-Aldrich
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ALDH5A1 siRNA (Human) - CRH5312 from Cohesion Biosciences
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ALDH5A1 - MBS8223362 from MyBioSource
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ALDH5A1 CRISPR/Cas9 KO Plasmid (h2) - sc-406757-KO-2 from Santa Cruz Biotechnology
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ALDH5A1 HDR Plasmid (h2) - sc-406757-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human ALDH5A1 (NM_001080.3) - SHH234938 from Creative biogene
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shRNA set against Human ALDH5A1(NM_170740.1) - SHG052823 from Creative biogene
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shRNA set against Human ALDH5A1(NM_001080.3) - SHG052973 from Creative biogene
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ALDH5A1 shRNA Plasmid (Human) - CHH5312 from Cohesion Biosciences
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ALDH5A1 miRNA 3'UTR clone - MiUTR1H-00292 from Creative biogene
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