| Gene Symbol |
VPS54
|
| Entrez Gene |
51542
|
| Alt Symbol |
HCC8, PPP1R164, SLP-8p, VPS54L, WR, hVps54L
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
vacuolar protein sorting 54 homolog (S. cerevisiae)
|
| Other Description |
hepatocellular carcinoma protein 8|protein phosphatase 1, regulatory subunit 164|tumor antigen HOM-HCC-8|tumor antigen SLP-8p|vacuolar protein sorting-associated protein 54
|
| Swissprots |
Q9NUJ0 Q86YF7 Q9NPV0 Q5VIR5 Q9P1Q0 Q9NT07 Q8N6G3
|
| Accessions |
EAW99952 Q9P1Q0 AF102177 AAF37319 AK002205 BAA92134 AK025545 AK094019 AK124436 AK292669 BAF85358 AK292889 BAF85578 AL137604 CAB70837 AL359939 CAB95772 AL514510 AW452246 AY444798 AAS20945 BC030275 AAH30275 BC041868 AAH41868 CR749701 CAH18479 DQ891080 ABM82006 DQ894262 ABM85188 XM_006712029 XP_006712092 XM_011532903 XP_011531205 XR_244939 NM_001005739 NP_001005739 NM_016516 NP_057600
|
| Function |
May be involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. {ECO:0000269|PubMed:18367545}.
|
| Subcellular Location |
Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:18367545}.
|
![Western Blot: VPS54 Overexpression Lysate (Adult Normal) [NBP2-07030] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for VPS54.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8492_VPS54%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-07030-img0001.jpg)