Gene Symbol | GGT5 |
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Entrez Gene | 2687 |
Alt Symbol | GGL, GGT 5, GGT-REL, GGTLA1 |
Species | Human |
Gene Type | protein-coding |
Description | gamma-glutamyltransferase 5 |
Other Description | gamma-glutamyl cleaving enzyme|gamma-glutamyl transpeptidase-related enzyme|gamma-glutamyl transpeptidase-related protein|gamma-glutamyltransferase-like activity 1|gamma-glutamyltranspeptidase 5|glutathione hydrolase 5|leukotriene-C4 hydrolase |
Swissprots | Q9UFM5 Q53XM9 P36269 Q6GMP0 Q96FC1 |
Accessions | EAW59643 EAW59644 EAW59645 P36269 AI581436 AK225661 AK226019 AK292006 BAF84695 AK293683 BAG57124 AK297869 BAG60196 AK304522 BAG65326 AK312401 AL117414 CAB55910 BC011362 AAH11362 BC073999 AAH73999 BT009808 AAP88810 BU728951 BX403504 BX425817 CT841518 CAJ86448 DQ891035 ABM81961 DQ894214 ABM85140 M64099 AAA58503 XM_005261557 XP_005261614 XM_005261558 XP_005261615 XM_011530133 XP_011528435 XM_011530134 XP_011528436 XM_011530135 XP_011528437 XM_011530136 XP_011528438 XM_011530137 XP_011528439 XM_011530138 XP_011528440 NM_001099781 NP_001093251 NM_001099782 NP_001093252 NM_001302464 NP_001289393 NM_001302465 NP_001289394 NM_004121 NP_004112 |
Function | Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4). |
Subcellular Location | Membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
Top Pathways | Taurine and hypotaurine metabolism, Glutathione metabolism, Arachidonic acid metabolism, Cyanoamino acid metabolism |
GGT5 CRISPR/Cas9 KO Plasmid (h) - sc-405055 from Santa Cruz Biotechnology
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GGT5 HDR Plasmid (h) - sc-405055-HDR from Santa Cruz Biotechnology
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GGT5 Double Nickase Plasmid (h) - sc-405055-NIC from Santa Cruz Biotechnology
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GGT5 Double Nickase Plasmid (h2) - sc-405055-NIC-2 from Santa Cruz Biotechnology
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GGT5 CRISPR Activation Plasmid (h) - sc-405055-ACT from Santa Cruz Biotechnology
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GGT5 CRISPR Activation Plasmid (h2) - sc-405055-ACT-2 from Santa Cruz Biotechnology
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GGT5 Lentiviral Activation Particles (h) - sc-405055-LAC from Santa Cruz Biotechnology
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GGT5 Lentiviral Activation Particles (h2) - sc-405055-LAC-2 from Santa Cruz Biotechnology
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GGT5 siRNA (h) - sc-40634 from Santa Cruz Biotechnology
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GGT5 shRNA Plasmid (h) - sc-40634-SH from Santa Cruz Biotechnology
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GGT5 shRNA (h) Lentiviral Particles - sc-40634-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN9264 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9264 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02037 from Sigma-Aldrich
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GGT5 siRNA (Human) - CRH1790 from Cohesion Biosciences
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GGT5 - MBS8229454 from MyBioSource
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shRNA set against Human GGT5 (NM_004121.2) - SHH300870 from Creative biogene
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shRNA set against Human GGTLA1(NM_004121.2) - SHH083621 from Creative biogene
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Human GGT5 siRNA - orb262292 from Biorbyt
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GGT5 shRNA Plasmid (Human) - CHH1790 from Cohesion Biosciences
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GGT5 miRNA 3'UTR clone - MiUTR1H-04025 from Creative biogene
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GGT5 miRNA 3'UTR clone - MiUTR3H-00854 from Creative biogene
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GGT5 miRNA 3'UTR clone - MiUTR3H-00855 from Creative biogene
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