| Gene Symbol |
spn-E
|
| Entrez Gene |
41919
|
| Alt Symbol |
CG3158, Dmel\CG3158, SPN-E, Spn-E, SpnE, fs(1)hls, fs(3)hls, hes, hls, homeless, spin-E, spn E, spn-E/hls, spnE
|
| Species |
Drosophila
|
| Gene Type |
protein-coding
|
| Description |
spindle E
|
| Other Description |
CG3158-PA|Spindle-E (homeless)|SpindleE|female sterile(3)homeless|homeless|homeless/spindle-E|spindle-E|spn-E-PA
|
| Swissprots |
Q9VF26 A2RVD0 Q26453
|
| Accessions |
AAF55235 AGA18845 Q9VF26 BT100306 ACZ52618 NM_057393 NP_476741
|
| Function |
Probable ATP-binding RNA helicase which plays a central role during spermatogenesis and oogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi and govern the methylation and subsequent repression of transposons. Involved in the repression of LTR retrotransposon copia. Also involved in telomere regulation by repressing specialized telomeric retroelements HeT-A, TAHRE, and TART; Drosophila telomeres being maintained by transposition of specialized telomeric retroelements. Involved in telomeric trans- silencing, a repression mechanism by which a transposon or a transgene inserted in subtelomeric heterochromatin has the capacity to repress in trans in the female germline, a homologous transposon, or transgene located in euchromatin. Involved in the repression of t
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Note=Component of the nuage, also named P granule, a germ-cell-specific organelle required to repress transposon during meiosis. {ECO:0000250}.
|