| Gene Symbol |
chmp2bb
|
| Entrez Gene |
405840
|
| Alt Symbol |
chmp2b, chmp2bl, zgc:77025
|
| Species |
Zebrafish
|
| Gene Type |
protein-coding
|
| Description |
charged multivesicular body protein 2Bb
|
| Other Description |
charged multivesicular body protein 2b|chromatin modifying protein 2B, like|chromatin modifying protein 2Bb|chromatin-modifying protein 2b
|
| Swissprots |
Q6NXD2 A2AVM3
|
| Accessions |
Q6NXD2 BC067142 AAH67142 FJ392633 NM_212904 NP_998069
|
| Function |
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000250}. Late endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
|
| Top Pathways |
Endocytosis
|