| Gene Symbol |
Got1
|
| Entrez Gene |
24401
|
| Alt Symbol |
Aspat, Gaspat, cAspAT, cCAT
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
glutamic-oxaloacetic transaminase 1, soluble
|
| Other Description |
aspartate aminotransferase 1|aspartate aminotransferase, cytoplasmic|cysteine aminotransferase, cytoplasmic|cysteine transaminase, cytoplasmic|cytosolic aspartate aminotransferase|glutamate oxaloacetate transaminase 1, soluble|transaminase A
|
| Swissprots |
Q64570 P13221 Q6P721
|
| Accessions |
AAA40842 CBF96063 CBF96226 CBV09583 CBV09746 EDL94253 EDL94254 P13221 BC061877 AAH61877 CB578328 CK600227 D00252 BAA00183 FM055803 FN802619 FQ219727 J04171 AAA40769 NM_012571 NP_036703
|
| Function |
Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3- mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. {ECO:0000269|PubMed:17545671, ECO:0000269|PubMed:21266983, ECO:0000269|PubMed:21361730, ECO:0000269|PubMed:3053674, ECO:0000269|PubMed:3182750, ECO:0000269|PubMed:7113743}.
|
| Subcellular Location |
Cytoplasm.
|
| Tissue Specificity |
Expressed in liver and kidney. {ECO:0000269|PubMed:3182856}.
|
| Top Pathways |
Cysteine and methionine metabolism, Alanine, aspartate and glutamate metabolism, Phenylalanine metabolism, Biosynthesis of amino acids, Tyrosine metabolism
|