| Gene Symbol |
Ucp2
|
| Entrez Gene |
22228
|
| Alt Symbol |
Slc25a8
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
uncoupling protein 2 (mitochondrial, proton carrier)
|
| Other Description |
UCP 2|UCPH|mitochondrial uncoupling protein 2|solute carrier family 25 member 8|uncoupling protein 2, mitochondrial
|
| Swissprots |
O88285 P70406
|
| Accessions |
AAD21150 BAA32532 BAA76592 EDL16447 EDL16448 EDL16449 EDL16450 EDL16451 EDL16452 P70406 AF111998 AAD17198 AF111999 AAD17199 AI325895 AK035298 BAC29021 AK054060 BAC35641 AK134116 BAE22021 AK142687 BAE25160 AK165245 AK172307 BC006072 BC012697 AAH12697 BC012967 AAH12967 BY299894 U69135 AAB17666 U94593 AAB53092 XM_006507579 XP_006507642 NM_011671 NP_035801
|
| Function |
UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Mitochondrion inner membrane {ECO:0000269|PubMed:21785437}; Multi-pass membrane protein {ECO:0000269|PubMed:21785437}.
|
| Tissue Specificity |
Highest in white adipose tissue, also detected in brown adipose tissue, heart and kidney. 4-6 times higher levels are detected in ob/ob and db/db mice.
|