| Gene Symbol |
PARP9
|
| Entrez Gene |
83666
|
| Alt Symbol |
ARTD9, BAL, BAL1, MGC:7868
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
poly (ADP-ribose) polymerase family, member 9
|
| Other Description |
ADP-ribosyltransferase diphtheria toxin-like 9|PARP-9|b aggressive lymphoma protein|poly (ADP-ribose) polymerase 9|poly [ADP-ribose] polymerase 9
|
| Swissprots |
E9PFM7 Q9BZL9 Q9BZL8 Q8TCP3 A8KA94 B2R8S9 Q8IXQ6
|
| Accessions |
EAW79477 EAW79478 EAW79479 Q8IXQ6 AB209742 BAD92979 AF307338 AAK07558 AF307339 AAK07559 AK092629 AK123412 AK125581 AK130147 AK292959 BAF85648 AK299107 BAH12952 AK313494 BAG36276 AL713679 CAD28483 AL832929 CAH56290 BC017463 BC039580 AAH39580 BP259272 BU675792 BX648869 CAH56133 DB096326 DC309545 DC368112 XM_005247820 XP_005247877 XM_011513218 XP_011511520 XM_011513219 XP_011511521 NM_001146102 NP_001139574 NM_001146103 NP_001139575 NM_001146104 NP_001139576 NM_001146105 NP_001139577 NM_001146106 NP_001139578 NM_031458 NP_113646
|
| Function |
In concert with DTX3L plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. Involved in inducing the expression of IFN-gamma-responsive genes. {ECO:0000269|PubMed:16809771, ECO:0000269|PubMed:23230272}.
|
| Subcellular Location |
Cytoplasm, cytosol. Nucleus. Note=Shuttles between the nucleus and the cytosol. Export to the cytosol depends on the interaction with DTX3L. Localizes at sites of DNA damage in a PARP1-dependent manner.
|
| Tissue Specificity |
Expressed in lymphocyte-rich tissues, spleen, lymph nodes, peripheral blood lymphocytes and colonic mucosa. Also expressed in nonhematopoietic tissues such as heart and skeletal muscle. Isoform 2 is the predominant form. Most abundantly expressed in lymphomas with a brisk host inflammatory response. In diffuse large B-cell lymphomas tumors, expressed specifically by malignant B-cells. {ECO:0000269|PubMed:11110709, ECO:0000269|PubMed:16809771}.
|