| Gene Symbol |
HLA-DPB1
|
| Entrez Gene |
3115
|
| Alt Symbol |
DPB1, HLA-DP, HLA-DP1B, HLA-DPB
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
major histocompatibility complex, class II, DP beta 1
|
| Other Description |
HLA DP14-beta chain|HLA class II histocompatibility antigen, DP beta 1 chain|HLA class II histocompatibility antigen, DP(W4) beta chain|HLA-DP histocompatibility type, beta-1 subunit|MHC HLA DPB1|MHC class II HLA-DP-beta-1|MHC class II HLA-DRB1|MHC class II antigen DP beta 1 chain|MHC class II antigen DPB1|MHC class II antigen DPbeta1|MHC class II antigen beta chain|beta1 domain MHC class II HLA DPB|class II HLA beta chain|major histocompatibility complex class II antigen beta chain
|
| Swissprots |
B7VF87 Q95IT8 Q29684 Q9XS11 Q5EP53 O98218 Q95IT7 Q0P0L4 Q29775 B9W6F9 Q5EP47 Q30050 O98219 B8ZYT0 Q6LBX4 C0MPQ5 Q5ENE1 Q4GY31 Q14279 Q5ISH5 Q5ENW3 Q30031 Q9TNT7 Q5STP2 O19698 O98223 Q30015 A5I886 C0MPQ6 Q4JHD8 Q29682 O46884 C4R9J5 Q8HWT5 Q30034 C0MPP5 Q9GIM4 B8ZX68 Q9GIM2 Q7YQ10 Q5I4H9 Q29776 Q8HWL7 Q860Z7 Q5EP56 Q5ISH4 Q30032 B5U8B4 Q5ENE0 C0MPQ2 Q30174 O19700 Q5YLA6 Q714U1 P13763 Q5SQ73 Q5I4H8 Q6LBX7 P79608 Q6TAS4 Q6LBX2 Q9BD13 Q29714 C0MPQ3 Q29880 Q9XS12 O77952 Q30033 A0PFJ7 O98217 Q29898 Q6IVX1 B9W5S8 C0MPQ7 O98216 C5IZL1 P79493 Q27S71 B9W6F7 P01916 Q9GIX6 O19749 Q6LBX6 Q0ZFN3 Q2MGW3 O98222 P04232 Q9MY67 Q29779 Q9GJ41 Q5EP49 Q9TQE2 A8YPB3 Q6LBX3 Q30052 O19702 Q29828 Q6LBX5 O00259 Q5EP46 Q29778 Q30051 Q29781 Q29977 Q6PWX6 Q5EP52 Q30053 B7VF80 Q29698 Q29879 Q5EP51 Q30055 Q29827 Q95HC1 Q714U2 Q30054 Q8SNC4 O98215 P04440
|
| Accessions |
AAA16928 AAA35994 AAA36255 AAA36256 AAA36257 AAA36258 AAA36259 AAA36260 AAA36261 AAA36262 AAA36263 AAA36264 AAA36265 AAA36266 AAA36310 AAA52663 AAA53476 AAA53477 AAA53479 AAA53480 AAA53481 AAA53482 AAA58441 AAA59650 AAA59690 AAA59719 AAA59720 AAA59721 AAA59722 AAA59723 AAA59724 AAA59725 AAA59726 AAA59727 AAA59728 AAA59730 AAA59731 AAA59732 AAA59733 AAA59734 AAA59735 AAA59736 AAA59737 AAA59738 AAA59740 AAA59741 AAA59742 AAA59743 AAA59744 AAA59745 AAA59746 AAA59747 AAA59748 AAA59750 AAA59751 AAA59752 AAA59753 AAA59828 AAA59843 AAA81335 AAB17108 AAB24928 AAB29915 AAB32181 AAB52511 AAB60413 AAB60414 AAC26835 AAC64232 AAD02200 AAD09481 AAD09482 AAD09483 AAD09484 AAD09485 AAD09486 AAD39682 AAD39683 AAF16938 AAF32279 AAF44659 AAG30143 AAG30144 AAK00264 AAK01673 AAK20867 AAK20868 AAK20869 AAK20870 AAK20871 AAK25777 AAK25778 AAK25779 AAK25780 AAK25781 AAK25782 AAK25783 AAK25784 AAK25785 AAK25786 AAK40344 AAK51161 AAK54754 AAK54755 AAK58508 AAL68647 AAL92172 AAM62425 AAN33050 AAO84761 AAO84762 AAO84763 AAO84764 AAO84765 AAO84766 AAO84767 AAO84768 AAQ12563 AAQ12564 AAQ88048 AAQ88049 AAQ88050 AAQ88051 AAQ88052 AAQ88053 AAQ88054 AAQ88055 AAQ88056 AAQ88057 AAQ88058 AAQ88059 AAQ88060 AAQ88061 AAQ88062 AAQ88063 AAQ88064 AAQ88065 AAQ88066 AAQ88067 AAQ88068 AAQ88069 AAQ88070 AAQ88071 AAQ88072 AAQ88073 AAQ88074 AAQ88075 AAQ88076 AAQ88077 AAQ88078 AAQ88079 AAQ88080 AAQ88081 AAQ88082 AAQ88083 AAQ88084 AAQ88085 AAQ88086 AAQ88087 AAQ88088 AAQ88089 AAQ88090 AAQ88091 AAQ88092 AAQ88093 AAQ88094 AAQ88095 AAQ88096 AAQ88097 AAR01826 AAR01828 AAR01830 AAR01832 AAR01834 AAR01836 AAR01838 AAR01840 AAR01842 AAR01844 AAR01846 AAR01848 AAR01850 AAR01852 AAR01854 AAR01856 AAR01858 AAR01860 AAR01862 AAR01864 AAR01866 AAR01868 AAR01870 AAR21105 AAR29060 AAS77869 AAT40308 AAT81151 AAW33682 AAW33683 AAW79272 AAY98352 AAZ13612 ABA33891 ABA33892 ABA33893 ABA33894 ABB17974 ABB91805 ABD36812 ABF47047 ABI93275 ABV72580 ACS12738 ADV78578 AEC33255 AFA43492 AFK31320 AFR69060 AFU93845 AFU93846 AFU93847 AFU93848 AFU93849 AFU93850 AFU93851 AFU93852 AFU93853 AFU93854 AFV46335 AFX62412 AFX62413 AFZ94525 AFZ94695 AGG68858 AGG68859 AGG79765 AGG79766 AGG79814 AGG79816 AGG79817 AGG79957 AGG79958 AGG79959 AGG79986 AGG79987 AGG79988 AGH25491 AGH25495 AGJ84111 AGK44371 AGK44372 AGK44373 AGK44374 AGK44375 AGL73170 AGL73171 AGL73172 AGM15309 AGT79687 AGT79688 AGT79689 AGT79690 AGT79691 AGT79692 AGT79693 AGT79694 AGT79695 AHA82520 AHB63680 AHC12375 AHW47933 AHW47950 AHW47967 AHW47984 AHY62007 AHY62008 AHY62009 AHY62010 AHY62011 AHY62012 AHY62013 AHY62014 AHY62015 AHY62016 AHY62017 AHY62018 AHY62019 AHY62020 AHY62021 AHY62022 AHY62023 AHY62025 AHY62026 AHY62027 AHY62029 AHY62032 AHY62033 AHY62034 AHY62035 AHY62036 AHY62037 AHY62038 AHY62039 AHY62040 AHY62041 AHY62042 AHY62043 AHY62044 AHY62045 AHY62046 AHY62047 AHY62048 AHY62049 AHY62050 AHY62052 AHY62053 AHY62054 AHY62055 AHY62056 AHY62057 AHY62058 AHY62059 AHY62060 AHY62061 AHY62062 AHY62063 AHY62064 AHY62065 AHY62066 AHY62068 AHY62070 AHY62071 AHY62072 AHY62073 AHY62074 AHY62075 AHY62076 AHY62077 AHY62078 AHY62079 AHY62080 AHY62081 AHY62082 AHY62083 AHY62084 AHY62085 AHY62086 AHY62087 AHY62089 AHY62090 AHY62091 AHY62092 AHY62093 AHY62094 AHY62095 AHY62096 AHY62097 AHY62098 AHY62099 AHY62100 AHY62101 AHY62102 AHY62103 AHY62104 AHY62105 AHY62106 AHY62107 AHY62108 AHY62109 AHY62110 AHY62111 AHY62112 AHY62113 AHY62114 AHY62115 AHY62116 AHY62117 AHY62118 AHY62119 AHY62120 AHY62121 AHY62122 AHY62123 AHY62125 AHY62126 AHY62127 AHY62128 AHY62129 AHY62130 AHY62131 AHY62132 AHY62134 AHY62135 AHY62136 AHY62137 AHY62138 AHY62139 AHY62140 AHY62141 AHY62142 AHY62143 AHY62144 AHY62145 AHY62146 AHY62147 AHY62148 AHY62149 AHY62150 AHY62151 AHY62152 AHY62153 AHY62154 AHY62155 AHY62156 AHY62157 AHY62158 AHY62159 AHY62161 AHY62162 AHY62164 AHY62165 AHY62166 AHY62168 AHY62169 AHY62170 AHY62171 AHY62172 AHY62173 AHY62175 AHY62176 AHY62178 AHY62179 AHY62181 AHY62182 AHY62183 AHY62185 AHY62186 AHY62187 AHY62188 AHY62189 AHY62190 AHY62191 AHY62192 AHY62193 AHY62194 AHY62195 AHY62196 AHY62197 AHY62198 AHY62199 AHY62200 AHY62201 AHY62202 AHY62203 AHY62205 AHY62207 AHY62208 AHY62209 AHY62210 AHY62211 AHY62212 AHY62213 AHY62214 AHY62215 AHY62216 AHY62217 AHY62219 AHY62222 AHY62223 AHY62224 AHY62225 AHY62226 AHY62227 AHY62228 AHY62230 AHY62232 AHY62233 AHY62235 AHY62236 AHY62237 AHY62238 AHY62239 AHY62242 AHY62243 AHY62244 AHY62245 AHY62246 AHY62247 AHY62248 AHY62249 AHY62250 AHY62251 AHY62252 AHY62253 AHY62254 AHY62255 AHY62256 AHY62257 AHY62259 AHY62260 AHY62261 AHY62263 AHY62264 AHY62265 AHY62266 AHY62267 AHY62268 AHY62269 AHY62270 AHY62271 AHY62272 AHY62274 AHY62275 AHY62276 AHY62277 AHY81839 AHY81840 AHY81841 AHY81842 AHY81843 AHY81844 AHY81845 AHY81846 AHY81847 AHY81848 AHY81849 AHY81850 AHY81851 AHY81852 AHY81853 AHY81854 AHY81855 AHY81856 AHY81857 AHY81858 AHY81859 AHY81860 AHY81861 AHY81862 AHY81863 AHY81864 AHY81865 AHY81867 AHY81868 AHY81869 AHY81871 AHY81872 AHY81873 AHY81874 AHY81875 AHY81876 AHY81877 AHY81878 AHY81879 AHY81880 AHY81881 AHY81882 AHY81883 AHY81884 AHY81885 AHY81886 AHY81887 AHY81889 AHY81890 AHY81891 AHY81892 AHY81893 AHY81894 AHY81895 AHY81896 AHY81897 AHY81898 AHY81899 AHY81900 AHY81901 AHY81902 AHY81903 AHY81905 AHY81906 AHY81907 AHY81908 AHY81909 AHY81910 AHY81911 AHY81912 AHY81913 AHY81914 AHY81915 AHY81916 AHY81917 AHY81920 AHY81921 AHY81922 AHY81923 AHY81924 AHY81925 AHY81926 AHY81927 AHY81928 AHY81929 AHY81930 AHY81931 AHY81932 AHY81933 AHY81934 AHY81936 AHY81937 AHY81938 AHY81940 AHY81942 AHY81943 AHY81944 AHY81945 AHY81946 AHY81947 AHY81948 AHY81949 AHY81950 AHY81952 AHY81953 AHY81954 AHY81955 AHY81956 AHY81957 AHY81958 AHY81959 AHY81960 AHY81961 AHY81962 AHY81963 AHY81964 AHY81965 AHY81966 AHY81967 AHY81968 AHY81969 AHY81970 AHY81971 AHY81972 AHY81973 AHY81974 AHY81975 AHY81976 AHY81977 AHY81978 AHY81979 AHY81980 AHY81981 AHY81982 AHY81983 AHY81984 AHY81985 AHY81986 AHY81987 AHY81988 AHY81989 AHY81990 AHY81991 AHY81992 AHY81993 AHY81994 AHY81995 AHY81996 AHY81997 AHY81998 AHY81999 AHY82000 AHY82001 AHY82002 AHY82003 AHY82004 AHY82005 AHY82006 AHY82007 AHY82008 AHY82009 AHY82010 AHY82011 AHY82012 AHY82013 AHY82014 AHY82015 AHY82016 AHY82017 AHY82018 AHY82019 AHY82020 AHY82021 AHY82022 AHY82023 AHY82024 AHY82026 AHY82027 AHY82028 AHY82029 AHY82030 AHY82031 AHY82032 AHY82033 AHY82034 AHY82035 AHY82036 AHY82037 AHY82038 AHY82039 AHY82040 AHY82041 AHY82042 AHY82044 AHY82045 AHY82046 AHY82048 AHY82049 AHY82050 AHY82051 AHY82052 AHY82053 AHY82054 AHY82055 AHY82056 AHY82057 AHY82058 AHY82059 AHY82060 AHY82061 AHY82062 AHY82063 AHY82064 AHY82065 AHY82066 AHY82067 AHY82068 AHY82069 AHY82070 AHY82071 AHY82072 AHY82073 AHY82074 AHY82075 AHY82076 AHY82077 AHY82078 AHY82079 AHY82081 AHY82082 AHY82083 AHY82084 AHY82086 AHY82087 AHY82088 AHY82089 AHY82090 AHY82091 AHY82093 AHY82095 AHY82096 AHY82098 AHY82099 AHY82100 AHY82101 AHY82102 AHY82103 AHY82104 AHY82105 AHY82106 AHY82107 AHY82108 AHZ31254 AHZ31255 AHZ31256 AHZ31257 AHZ31258 AHZ31259 AHZ31260 AHZ31263 AHZ31264 AHZ31265 AHZ31266 AHZ31267 AHZ31268 AHZ31269 AHZ31270 AHZ31271 AHZ31272 AHZ31273 AHZ31274 AHZ31275 AHZ31276 AHZ31277 AHZ31278 AHZ31279 AHZ31280 AHZ31281 AHZ31282 AHZ31283 AHZ31284 AHZ31285 AHZ31286 AHZ31287 AHZ31288 AHZ31290 AHZ31291 AHZ31292 AHZ31293 AHZ31294 AHZ31295 AHZ31296 AHZ31297 AHZ31298 AHZ31299 AHZ31300 AHZ31301 AHZ31302 AHZ31303 AHZ31304 AHZ31306 AHZ31307 AHZ31309 AHZ31310 AHZ31312 AHZ31314 AHZ31315 AHZ31316 AHZ31317 AHZ31318 AHZ31319 AHZ31320 AHZ31321 AHZ31322 AHZ31323 AHZ31324 AHZ31325 AHZ31326 AHZ31327 AHZ31328 AHZ31329 AHZ31330 AHZ31331 AHZ31332 AHZ31333 AHZ31334 AHZ31336 AHZ31337 AHZ31338 AHZ31339 AHZ31340 AHZ31341 AHZ31342 AHZ31343 AHZ31344 AHZ31345 AHZ31346 AHZ31347 AHZ31348 AHZ31349 AHZ31350 AHZ31351 AHZ31352 AHZ31354 AHZ31356 AHZ31358 AHZ31359 AHZ31360 AHZ31361 AHZ31362 AHZ31363 AHZ31364 AHZ31367 AHZ31368 AHZ31369 AHZ31370 AHZ31371 AHZ31372 AHZ31373 AHZ31374 AHZ31375 AHZ31376 AHZ31377 AHZ31378 AHZ31379 AHZ31380 AHZ31381 AHZ31382 AHZ31383 AHZ31385 AHZ31386 AHZ31387 AHZ31388 AIL02137 AJL35056 AJP61153 BAA01281 BAA01282 BAA01614 BAA01704 BAA02465 BAA03278 BAA05970 BAE78492 BAN59781 BAN59787 BAN59793 BAN59799 BAN59805 BAN59811 BAN59817 BAN59823 BAN59829 BAN59835 BAN59841 BAN59847 CAA26147 CAA26823 CAA26886 CAA56581 CAA56728 CAA57635 CAA65710 CAA66059 CAA70086 CAA70507 CAA74199 CAA74608 CAA76060 CAB06822 CAB53016 CAB70605 CAC12860 CAC12865 CAC14048 CAC27995 CAD55852 CAD91639 CAD91640 CAE46432 CAE82007 CAE82008 CAE82037 CAE82042 CAE82043 CAE82073 CAH18733 CAJ01690 CAJ43602 CAL64063 CAP08783 CAR66423 CAR66500 CAR66501 CAR66502 CAT03206 CAT04585 CAX11690 CAX20314 CAX21583 CAX30405 CAX30406 CAX30407 CAX53275 CAX53717 CAX53718 CAX53721 CAX53722 CAX53724 CAX53726 CAY85528 CBF04503 CBG91975 CBG92013 CBH51782 CBH51783 CBI67622 CBI68355 CBI69377 CBJ05875 CBL43006 CBL43262 CBL86578 CBV44423 CBW38505 CBX25819 CBX32807 CCA30657 CCA30658 CCD35051 CCE60543 CCE73674 CCM44319 CCM44320 CCP01066 CDG24316 CDG31901 CDO33926 CDO67961 CDO67962 CDO67963 CDO67964 CDU84838 CDU84839 CEJ95827 CEJ95828 CEJ95829 CEJ95830 CEJ95831 CEO43653 CQR91449 CQR91450 CQR91451 CQR91452 CQR91453 CQR91454 CQR91455 CQR91456 CQR91457 CQR91458 CQR91459 CQR91460 CQR91461 EAX03672 EAX03673 EAX03674 EAX03675 P04440 AB208978 BAD92215 AB936562 BAP47705 AK291986 BAF84675 AK301322 BAG62871 AK303153 BAG64256 AK313305 BAG36110 AY656678 AAV71025 AY656679 AAV71026 AY656680 AAV71027 AY804132 AAW78737 AY804133 AAW78738 AY804134 AAW78739 AY804135 AAW78740 AY804136 AAW78741 AY804137 AAW78742 AY804138 AAW78743 AY804139 AAW78744 AY804140 AAW78745 AY804141 AAW78746 AY804142 AAW78747 AY804143 AAW78748 AY831401 AAW80919 AY831402 AAW80920 AY831403 AAW80921 AY831404 AAW80922 BC007963 AAH07963 BC013184 AAH13184 BC015000 AAH15000 BP213121 BT019780 AAV38583 DQ284441 ABC66207 DQ891050 ABM81976 DQ894229 ABM85155 FR775797 CBY94059 FR775798 CBY94060 GQ891549 ACX50636 HE603611 CCE21695 HE603612 CCE21696 HE614584 CCE73901 HE614585 CCE73902 HE614586 CCE73903 HE614587 CCE73904 HE614588 CCE73905 HE614589 CCE73906 HE614590 CCE73907 HE614591 CCE73908 J03041 AAA35993 K00409 AAA36312 K01615 AAA36313 KJ780721 AII72202 L29173 AAA36311 M21886 AAA59739 M28200 AAA53195 M28201 AAA53196 M28202 AAA53197 M57466 AAA63221 M83664 AAA59837 S66883 AAB28826 X00532 CAA25210 X01426 CAA25672 X03067 CAA26871 XM_006715078 XP_006715141 XM_006725040 XP_006725103 XM_006725699 XP_006725762 XM_006725817 XP_006725880 XM_006725908 XP_006725971 XM_006725998 XP_006726061 XM_006726088 XP_006726151 NM_002121 NP_002112
|
| Function |
Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loa
|
| Subcellular Location |
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single- pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.
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| Top Pathways |
Inflammatory bowel disease (IBD), HTLV-I infection, Influenza A, Tuberculosis, Herpes simplex infection
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