| Gene Symbol | PRELID1 |
|---|---|
| Entrez Gene | 27166 |
| Alt Symbol | CGI-106, PRELI, PX19, SBBI12 |
| Species | Human |
| Gene Type | protein-coding |
| Description | PRELI domain containing 1 |
| Other Description | 25 kDa protein of relevant evolutionary and lymphoid interest|PRELI domain-containing protein 1, mitochondrial|px19-like protein |
| Swissprots | Q9UJS9 Q549N2 Q9UI13 B2R5F7 D6RD25 Q9Y255 |
| Accessions | EAW85021 EAW85022 EAW85023 Q9Y255 AA844687 AF087858 AAP97168 AF111112 AAF27195 AF112203 AAF17191 AF151864 AAD34101 AF153607 AAD41089 AF201925 AAF09255 AK312170 BAG35104 BC000007 AAH00007 BC007268 AAH07268 BC008307 AAH08307 BC008866 AAH08866 BC013733 AAH13733 BC013748 AAH13748 BC018904 BG739785 BU956915 DQ891042 ABM81968 DQ894221 ABM85147 U94779 NM_001271828 NP_001258757 NM_013237 NP_037369 |
| Function | Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Regulates the mitochondrial apoptotic pathway in primary Th cells. Regulates Th cell differentiation by down-regulating STAT6 thereby reducing IL-4-induced Th2 cell number. May be important for the development of vital and immunocompetent organs. {ECO:0000269|PubMed:18945965, ECO:0000269|PubMed:21364629, ECO:0000269|PubMed:23931759}. |
| Subcellular Location | Mitochondrion. Mitochondrion intermembrane space {ECO:0000269|PubMed:14640972, ECO:0000269|PubMed:18945965, ECO:0000269|PubMed:21364629, ECO:0000269|PubMed:23931759}. |
| Tissue Specificity | Highly expressed in fetal liver; less expressed in fetal brain, lung, and kidney. At the adult stage, expression is drastically reduced in the liver but highly expressed in the spleen, brain, lung, lymph nodes and peripheral blood leukocytes. |
PRELI CRISPR/Cas9 KO Plasmid (h) - sc-411975 from Santa Cruz Biotechnology
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PRELI HDR Plasmid (h) - sc-411975-HDR from Santa Cruz Biotechnology
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PRELI Double Nickase Plasmid (h) - sc-411975-NIC from Santa Cruz Biotechnology
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PRELI Double Nickase Plasmid (h2) - sc-411975-NIC-2 from Santa Cruz Biotechnology
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PRELI CRISPR Activation Plasmid (h) - sc-411975-ACT from Santa Cruz Biotechnology
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PRELI CRISPR Activation Plasmid (h2) - sc-411975-ACT-2 from Santa Cruz Biotechnology
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PRELI Lentiviral Activation Particles (h) - sc-411975-LAC from Santa Cruz Biotechnology
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PRELI Lentiviral Activation Particles (h2) - sc-411975-LAC-2 from Santa Cruz Biotechnology
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PRELI siRNA (h) - sc-76242 from Santa Cruz Biotechnology
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PRELI shRNA Plasmid (h) - sc-76242-SH from Santa Cruz Biotechnology
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PRELI shRNA (h) Lentiviral Particles - sc-76242-V from Santa Cruz Biotechnology
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PX19 RNAi - H00027166-R01 from Novus Biologicals
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MISSION® esiRNA - EHU104871 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17389 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17389 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02952 from Sigma-Aldrich
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PRELID1 siRNA (Human) - CRH9006 from Cohesion Biosciences
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shRNA set against Human PRELID1 (NM_013237.2) - SHH382384 from Creative biogene
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shRNA set against Human PRELID1(NM_013237.2) - SHR138402 from Creative biogene
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Human PRELID1 siRNA - orb269508 from Biorbyt
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PRELID1 shRNA Plasmid (Human) - CHH9006 from Cohesion Biosciences
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PRELID1 miRNA 3'UTR clone - MiUTR1H-08240 from Creative biogene
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