Gene Symbol |
CD86
|
Entrez Gene |
942
|
Alt Symbol |
B7-2, B7.2, B70, CD28LG2, LAB72
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
CD86 molecule
|
Other Description |
B-lymphocyte activation antigen B7-2|BU63|CD86 antigen (CD28 antigen ligand 2, B7-2 antigen)|CTLA-4 counter-receptor B7.2|FUN-1|T-lymphocyte activation antigen CD86
|
Swissprots |
E7ETN5 Q7M4L5 Q6GTS4 E9PC27 B7Z702 A0N0P0 B7Z2F3 P42081 Q13655 Q6FHB1
|
Accessions |
AAA86473 ABK41931 CDM22279 EAW79493 EAW79494 P42081 AK291497 BAF84186 AK294663 BAH11839 AK301237 BAH13438 AK313103 BAG35926 AK316203 BAH14574 BC040261 AAH40261 BX093060 CD705810 CR541844 CAG46642 DA619360 DQ890617 ABM92234 DQ893787 ABM84713 L25259 AAA58389 U04343 AAB03814 NM_001206924 NP_001193853 NM_001206925 NP_001193854 NM_006889 NP_008820 NM_175862 NP_787058 NM_176892 NP_795711
|
Function |
Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T- cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.
|
Subcellular Location |
Cell membrane; Single-pass type I membrane protein.
|
Tissue Specificity |
Expressed by activated B-lymphocytes and monocytes.
|
Top Pathways |
Type I diabetes mellitus, Graft-versus-host disease, Allograft rejection, Autoimmune thyroid disease, Intestinal immune network for IgA production
|