CD86

Gene Symbol	CD86
Entrez Gene	942
Alt Symbol	B7-2, B7.2, B70, CD28LG2, LAB72
Species	Human
Gene Type	protein-coding
Description	CD86 molecule
Other Description	B-lymphocyte activation antigen B7-2|BU63|CD86 antigen (CD28 antigen ligand 2, B7-2 antigen)|CTLA-4 counter-receptor B7.2|FUN-1|T-lymphocyte activation antigen CD86
Swissprots	E7ETN5 Q7M4L5 Q6GTS4 E9PC27 B7Z702 A0N0P0 B7Z2F3 P42081 Q13655 Q6FHB1
Accessions	AAA86473 ABK41931 CDM22279 EAW79493 EAW79494 P42081 AK291497 BAF84186 AK294663 BAH11839 AK301237 BAH13438 AK313103 BAG35926 AK316203 BAH14574 BC040261 AAH40261 BX093060 CD705810 CR541844 CAG46642 DA619360 DQ890617 ABM92234 DQ893787 ABM84713 L25259 AAA58389 U04343 AAB03814 NM_001206924 NP_001193853 NM_001206925 NP_001193854 NM_006889 NP_008820 NM_175862 NP_787058 NM_176892 NP_795711
Function	Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T- cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.
Subcellular Location	Cell membrane; Single-pass type I membrane protein.
Tissue Specificity	Expressed by activated B-lymphocytes and monocytes.
Top Pathways	Type I diabetes mellitus, Graft-versus-host disease, Allograft rejection, Autoimmune thyroid disease, Intestinal immune network for IgA production

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human CD86 protein fragment - ab167720 from Abcam Category Protein Prices $465.00 Sizes 200 µg Source HEK 293 cells Species Human

Human CD86 full length protein - ab114228 from Abcam Category Protein Prices $420.00 Sizes 10 µg Source Wheat germ Species Human

Human CD86 full length protein - ab134871 from Abcam Category Protein Prices $188.00 Sizes 100 µg Source E. coli Species Human

Human CD86 peptide - ab104392 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Human CD86 protein fragment - ab114229 from Abcam Category Protein Prices $420.00 Sizes 10 µg Source Wheat germ Species Human

Human CD86 protein fragment - ab151804 from Abcam Category Protein Prices $188.00 Sizes 10 µg Source HEK 293 cells Species Human

Human CD86 protein fragment - ab198448 from Abcam Category Protein Prices $625.00 Sizes 100 µg Source HEK 293 cells Species Human

CD86 Antibody Blocking Peptide - LS-E3909 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CD86 Antibody Blocking Peptide - LS-E22986 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CD86 Antibody Blocking Peptide - LS-E22987 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

B7-2/CD86 Recombinant Protein - H00000942-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

B7-2/CD86 Partial Recombinant Protein - H00000942-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

B7-2/CD86 Recombinant Protein - H00000942-G01 from Novus Biologicals Category Protein Prices $579.00 Sizes 10 µg Species Human

CD86-Antibody-C-term-Blocking-Peptide - BP16101b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human B7-2/CD86 Fc Chimera, CF - 141-B2-100 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Recombinant Mouse B7-2/CD86 Fc Chimera, CF - 741-B2-100 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived

Recombinant Human B7-2/CD86 Fc Chimera (CHO-expressed), CF - 7625-B2-100 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived

Recombinant Rat B7-2/CD86 Fc Chimera, CF - 1340-B2-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Human CD86 protein - orb49287 from Biorbyt Category Protein Prices $213.00, $408.00, $1,411.00, $1,981.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Source HEK293

CD86 peptide - orb72503 from Biorbyt Category Peptide Prices $238.00 Sizes 500 µg

Human LAB7-2 Protein - abx065548 from Abbexa Category Protein Source E.coli Species Human

CD86 (Fc portion) - AR31193PU-N from Acris Antibodies Category Protein Prices $235.00 Sizes 100 µg Source CHO cells Species Human

CD86 (Fc portion) - AR31193PU-S from Acris Antibodies Category Protein Prices $135.00 Sizes 20 µg Source CHO cells Species Human

CD86 - H00000942-G01 from Acris Antibodies Category Protein Prices $550.00 Sizes 10 µg Species Human

CD86 - H00000942-H01 from Acris Antibodies Category Protein Prices $770.00 Sizes 25 µg Source Human HEK293T cells Species Human

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