| Gene Symbol |
Mapk8ip1
|
| Entrez Gene |
19099
|
| Alt Symbol |
IB1, JIP-1, Jip1, Prkm8ip, Skip, mjip-2a
|
| Species |
Mouse
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| Gene Type |
protein-coding
|
| Description |
mitogen-activated protein kinase 8 interacting protein 1
|
| Other Description |
C-Jun-amino-terminal kinase-interacting protein 1|IB-1|JNK MAP kinase scaffold protein 1|JNK-interacting protein 1|islet-brain-1|mitogen activated protein kinase 8 interacting protein 1|mitogen-activated protein kinase 8-interacting protein 1|protein kinase, mitogen-activated 8 interacting protein
|
| Swissprots |
Q9R1Z1 Q9WVI7 Q925J8 O35145 Q9R1H9 Q9WVI8 Q9WVI9
|
| Accessions |
EDL27600 EDL27601 EDL27602 EDL27603 EDL27604 Q9WVI9 AB221603 AF003115 AAB66317 AF054611 AAD22580 AF109768 AAD38346 AF109769 AAD38347 AF109770 AAD38348 AF109771 AAD38349 AF332075 AAK56103 AF332076 AAK56104 AK053819 AK147033 BAE27625 AK179094 AK192659 AK217001 AK218579 AK219726 BC072578 AAH72578 XM_006498953 XP_006499016 XM_006498954 XP_006499017 NM_001202445 NP_001189374 NM_001202446 NP_001189375 NM_011162 NP_035292
|
| Function |
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK- regulated activity by retaining JNK in the cytoplasm and thus inhibiting the JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Nucleus {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}. Mitochondrion membrane {ECO:0000250}. Note=Accumulates in cell surface projections. Under certain stress conditions, translocates to the perinuclear region of neurons. In insulin-secreting cells, detected in both the cytoplasm and nucleus (By similarity). {ECO:0000250}.
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| Tissue Specificity |
Expressed predominantly in the brain and insulin-secreting cells. In the brain, high expression found in the cerebral cortex and hippocampus. Localizes in the synaptic regions of the olfactory bulb, retina, cerebral and cerebellar cortex and hippocampus. Also expressed in a restricted number of axons, including mossy fibers from the hippocampal dentate gyrus, soma, dendrites and axons of cerebellar Purkinje cells. Also expressed in kidney, testis and prostate. Low levels in heart, ovary and small intestine. Isoform JIP-1b is more predominant in the brain than isoform JIP-1a. Isoform Jip1-a is expressed both in the brain and kidney, isoform JIP-1c, isoform JIP-1d and isoform JIP-1e are brain specific. {ECO:0000269|PubMed:10712642}.
|
| Top Pathways |
MAPK signaling pathway
|