| Gene Symbol |
TCAF2
|
| Entrez Gene |
285966
|
| Alt Symbol |
FAM115C, FAM139A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
TRPM8 channel-associated factor 2
|
| Other Description |
TRP channel-associated factor 2|family with sequence similarity 115, member C|family with sequence similarity 139, member A|protein FAM115C
|
| Swissprots |
Q17RQ4 A6NFQ2 B4DK02 Q8IWQ0 Q8NF84 Q14D25
|
| Accessions |
A6NFQ2 EAL23793 EAW50491 AK090395 BAC03376 AK098041 BAC05220 AK296318 BAG59014 AL832734 AY167570 AAN87343 BC113530 AAI13531 BC117233 AAI17234 CN479606 DC299572 DC402602 EU831922 ACE87363 EU832016 ACE86678 HQ258592 ADR83345 HQ258634 ADR83386 XM_006715927 XP_006715990 XM_006715928 XP_006715991 XM_011516059 XP_011514361 NM_001130025 NP_001123497 NM_001130026 NP_001123498 NM_173678 NP_775949
|
| Function |
Isoform 2: Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner. {ECO:0000269|PubMed:25559186}.
|
| Subcellular Location |
Isoform 2: Cell membrane {ECO:0000269|PubMed:25559186}. Note=Colocalizes with TRPM8 on the plasma membrane. {ECO:0000269|PubMed:25559186}.
|
| Tissue Specificity |
Isoform 2 is expressed in the prostate and in cancerous prostate samples. {ECO:0000269|PubMed:25559186}.
|