Cth

Gene Symbol	Cth
Entrez Gene	24962
Alt Symbol	H
Species	Rat
Gene Type	protein-coding
Description	cystathionine gamma-lyase
Other Description	CTL target antigen\|PRB-RA\|cystathionase (cystathionine gamma-lyase)\|cysteine-protein sulfhydrase\|gamma-cystathionase\|probasin-related antigen
Swissprots	P18757
Accessions	CBF67270 CBU92143 EDL82568 P18757 AB052882 BAB19922 AY032875 AAK52091 AY641456 BC078869 AAH78869 D17370 BAA04189 X53460 CAA37547 XM_006233536 XP_006233598 NM_017074 NP_058770
Function	Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function (By similarity). {ECO:0000250}.
Subcellular Location	Cytoplasm.
Top Pathways	Glycine, serine and threonine metabolism, Cysteine and methionine metabolism, Selenocompound metabolism, Biosynthesis of amino acids

Category	Protein
Source	Yeast or E.coli or Baculovirus or Mammalian cell
Species	Rat

Category	Protein
Prices	$1,170.00, $1,170.00, $1,400.00, $1,400.00, $1,875.00, $1,875.00, $2,340.00, $2,340.00
Sizes	500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source	E Coli or Yeast or Baculovirus or Mammalian Cell
Species	Rat

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