| Gene Symbol |
KIF4A
|
| Entrez Gene |
24137
|
| Alt Symbol |
KIF4, KIF4G1, MRX100
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
kinesin family member 4A
|
| Other Description |
chromokinesin-A|chromosome-associated kinesin KIF4A
|
| Swissprots |
Q9NNY6 Q86TN3 Q9UMW3 Q86XX7 B2R7V5 O95239 D3DVU4 Q9NY24
|
| Accessions |
EAX05341 EAX05342 EAX05343 O95239 AB208797 BAD92034 AF071592 AAD05492 AF179308 AAD51855 AF277375 AAF86334 AJ271784 CAB75427 AK000638 AK022592 AK022717 AK024266 BAG51282 AK313133 BAG35952 AW592235 BC003664 AAH03664 BC011801 BC038459 BC049218 AAH49218 BC050548 AAH50548 DA021880 XM_011530893 XP_011529195 NM_012310 NP_036442
|
| Function |
Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization. {ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105}.
|
| Subcellular Location |
Nucleus matrix. Cytoplasm, cytoskeleton, spindle. Midbody. Chromosome. Note=Not present in the nucleolus. In early mitosis, associated with the mitotic spindle, in anaphase, localized to the spindle midzone and, in telophase and cytokinesis, to the midbody. In late cytokinesis, found in the center of the midbody. Associated with chromosomes at all stages of mitosis.
|
| Tissue Specificity |
Highly expressed in hematopoietic tissues, fetal liver, spleen, thymus and adult thymus and bone marrow. Lower levels are found in heart, testis, kidney, colon and lung. {ECO:0000269|PubMed:10978527}.
|
