| Gene Symbol |
GABBR2
|
| Entrez Gene |
9568
|
| Alt Symbol |
GABABR2, GPR51, GPRC3B, HG20, HRIHFB2099
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
gamma-aminobutyric acid (GABA) B receptor, 2
|
| Other Description |
G protein-coupled receptor 51|G-protein coupled receptor 51|GABA-B receptor 2|GABA-B receptor, R2 subunit|GABA-B-R2|GABA-BR2|gamma-aminobutyric acid B receptor 2|gamma-aminobutyric acid type B receptor subunit 2|gb2
|
| Swissprots |
Q9UNS9 Q5VXZ2 O75975 O75899 Q9P1R2 Q8WX04 Q9UNR1 O75974
|
| Accessions |
CAI79357 EAW58889 EAW58890 EAW58891 O75899 AB015334 BAA34793 AF056085 AAC63228 AF069755 AAC99345 AF074483 AAD03336 AF095784 AAD30389 AF099033 AAD45867 AJ012188 CAA09942 AK308139 BC031317 BC035071 AAH35071 BC055425 BX420187 BX452140 DB474482 DQ891731 ABM82657 DQ894908 ABM85834 JQ308173 AFF59483 XM_005252316 XP_005252373 NM_005458 NP_005449
|
| Function |
Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic po
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Coexpression of GABBR1 and GABBR2 is required for GABBR1 maturation and transport to the plasma membrane. In contrast, GABBR2 does not depend on GABBR1 for transport to the cell membrane.
|
| Tissue Specificity |
Highly expressed in brain, especially in cerebral cortex, thalamus, hippocampus, frontal, occipital and temporal lobe, occipital pole and cerebellum, followed by corpus callosum, caudate nucleus, spinal cord, amygdala and medulla. Weakly expressed in heart, testis and skeletal muscle. {ECO:0000269|PubMed:10087195, ECO:0000269|PubMed:10328880, ECO:0000269|PubMed:10727622}.
|
| Top Pathways |
GABAergic synapse, Morphine addiction, Estrogen signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction
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