Gene Symbol | MFF |
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Entrez Gene | 56947 |
Alt Symbol | C2orf33, GL004 |
Species | Human |
Gene Type | protein-coding |
Description | mitochondrial fission factor |
Other Description | - |
Swissprots | Q9H690 Q9NRG8 Q9GZY8 Q567U1 Q9BVZ1 Q658R6 |
Accessions | AAY24252 EAW70859 EAW70860 EAW70861 EAW70862 EAW70863 EAW70864 EAW70865 EAW70866 EAW70867 EAW70868 EAW70869 Q9GZY8 AA629429 AF226049 AAF86949 AF246239 AAG44486 AF258660 AAG44658 AK026137 BAB15373 AL517791 AL559606 AL833032 CAH56328 BC000797 AAH00797 BC093024 AAH93024 BI550249 BQ653061 DA737008 DB043777 W58482 XM_005246681 XP_005246738 XM_005246682 XP_005246739 XM_005246683 XP_005246740 XM_005246684 XP_005246741 XM_005246685 XP_005246742 XM_005246686 XP_005246743 XM_005246687 XP_005246744 XM_005246688 XP_005246745 XM_006712637 XP_006712700 XM_006712638 XP_006712701 XM_006712639 XP_006712702 XM_011511500 XP_011509802 XM_011511501 XP_011509803 XM_011511502 XP_011509804 NM_001277061 NP_001263990 NM_001277062 NP_001263991 NM_001277063 NP_001263992 NM_001277064 NP_001263993 NM_001277065 NP_001263994 NM_001277066 NP_001263995 NM_001277067 NP_001263996 NM_001277068 NP_001263997 NM_020194 NP_064579 NR_102266 |
Function | Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles. {ECO:0000269|PubMed:18353969, ECO:0000269|PubMed:23530241}. |
Subcellular Location | Mitochondrion outer membrane; Single-pass type IV membrane protein. Peroxisome. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250}. |
Tissue Specificity | Highly expressed in heart, kidney, liver, brain, muscle, and stomach. {ECO:0000269|PubMed:18353969}. |
MFF CRISPR/Cas9 KO Plasmid (h) - sc-402756 from Santa Cruz Biotechnology
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MFF HDR Plasmid (h) - sc-402756-HDR from Santa Cruz Biotechnology
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MFF Double Nickase Plasmid (h) - sc-402756-NIC from Santa Cruz Biotechnology
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MFF Double Nickase Plasmid (h2) - sc-402756-NIC-2 from Santa Cruz Biotechnology
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MFF CRISPR Activation Plasmid (h) - sc-402756-ACT from Santa Cruz Biotechnology
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MFF CRISPR Activation Plasmid (h2) - sc-402756-ACT-2 from Santa Cruz Biotechnology
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MFF Lentiviral Activation Particles (h) - sc-402756-LAC from Santa Cruz Biotechnology
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MFF Lentiviral Activation Particles (h2) - sc-402756-LAC-2 from Santa Cruz Biotechnology
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MFF siRNA (h) - sc-94736 from Santa Cruz Biotechnology
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MFF shRNA Plasmid (h) - sc-94736-SH from Santa Cruz Biotechnology
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MFF shRNA (h) Lentiviral Particles - sc-94736-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU114851 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN13250 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13250 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06179 from Sigma-Aldrich
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MFF siRNA (Human) - CRJ1246 from Cohesion Biosciences
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shRNA set against Human C2orf33(NM_020194.4) - SHG123837 from Creative biogene
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Human MFF siRNA - orb271747 from Biorbyt
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MFF shRNA Plasmid (Human) - CHJ1246 from Cohesion Biosciences
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MFF miRNA 3'UTR clone - MiUTR1H-01367 from Creative biogene
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