| Gene Symbol |
Lgr5
|
| Entrez Gene |
299802
|
| Alt Symbol |
Gpr49
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
leucine rich repeat containing G protein coupled receptor 5
|
| Other Description |
G protein-coupled receptor 49|leucine-rich repeat-containing G-protein coupled receptor 5
|
| Swissprots |
D4AC13
|
| Accessions |
D4AC13 EDM16685 NM_001106784 NP_001100254
|
| Function |
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R- spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Rapidly and constitutively internalized to the trans-Golgi network at steady state. {ECO:0000250}.
|