| Gene Symbol |
PSTPIP1
|
| Entrez Gene |
9051
|
| Alt Symbol |
CD2BP1, CD2BP1L, CD2BP1S, H-PIP, PAPAS, PSTPIP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
proline-serine-threonine phosphatase interacting protein 1
|
| Other Description |
CD2 antigen-binding protein 1|CD2 cytoplasmic tail-binding protein|CD2-binding protein 1|PEST phosphatase-interacting protein 1|proline-serine-threonine phosphatase-interacting protein 1
|
| Swissprots |
O95657 O43585 B5BU74 O43586 B5BUK4
|
| Accessions |
AHH28343 CCQ77685 EAW99213 EAW99214 EAW99215 O43586 AB451310 BAG70124 AB451440 BAG70254 AF038602 AAD11958 AF038603 AAD11959 AK298733 BAG60882 AK304052 BAG64961 AK308462 AK309856 AK310072 AK310126 AK316220 BAH14591 AL110110 BC008602 AAH08602 DB123759 DQ891779 ABM82705 DQ894963 ABM85889 U94778 AAD00762 XM_006720737 XP_006720800 XM_011522163 XP_011520465 XM_011522164 XP_011520466 XM_011522165 XP_011520467 XM_011522166 XP_011520468 XM_011522167 XP_011520469 XM_011522168 XP_011520470 XM_011522169 XP_011520471 XM_011522170 XP_011520472 XM_011522171 XP_011520473 XM_011522172 XP_011520474 XM_011522173 XP_011520475 XR_931936 XR_931937 XR_931938 XR_931939 XR_931940 NM_003978 NP_003969
|
| Function |
Involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation (By similarity). Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2. Also has a role in innate immunity and the inflammatory response. Recruited to inflammasomes by MEFV. Induces formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Binding to MEFV allows MEFV to bind to PYCARD and facilitates pyroptosome formation. Regulates endocytosis and cell migration in neutrophi
|
| Subcellular Location |
Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, lamellipodium {ECO:0000250}. Cell projection, uropodium. Cytoplasm, perinuclear region {ECO:0000250}. Cleavage furrow {ECO:0000250}. Note=During interphase, colocalizes with F- actin in the cortical cytoskeleton, lamellipodia, and stress fibers. In dividing cells, colocalizes with the F-actin rich cytokinetic cleavage furrow. Colocalized with WAS to filamentous structures within the cytoplasm. Colocalized with PTPN12 in the cytoplasm and the perinuclear region. Colocalized with CD2AP and WAS in the actin cytoskeleton. Colocalized with CD2, CD2AP and WAS at the site of T-cell:APC contact (By similarity). In monocytes, forms a branched filamentous network in the cytoplasm. In migrating neutrophils, localizes most strongly to the trailing edge of the uropod where it colocalizes with PIP5K1C. In transfected cells, forms relatively straight filaments radiating out from the nucleus. Colocalizes with MEFV, particularly at the branch point o
|
| Tissue Specificity |
Highly expressed in the peripheral blood leukocytes, granulocytes and monocytes, namely in T-cells and natural killer cells, and in spleen. Weakly expressed in the thymus, small intestine, lung and placenta. {ECO:0000269|PubMed:14595024, ECO:0000269|PubMed:9857189}.
|
| Top Pathways |
NOD-like receptor signaling pathway
|