| Gene Symbol |
Baat
|
| Entrez Gene |
12012
|
| Alt Symbol |
AI118337, AI158864, BAT
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
bile acid-Coenzyme A: amino acid N-acyltransferase
|
| Other Description |
BACAT|bile acid-CoA:amino acid N-acyltransferase|bile acid-Coenzyme A dehydrogenase: amino acid n-acyltransferase|glycine N-choloyltransferase|long-chain fatty-acyl-CoA hydrolase|taurine N-acyltransferase
|
| Swissprots |
Q8C1I3 Q91X34 O08833 A2AKK7
|
| Accessions |
EDL02319 Q91X34 AA255212 AK017923 BAC25534 BB800891 BC012683 BY080271 CB947692 U95215 AAB58325 XM_006537565 XP_006537628 NM_007519 NP_031545
|
| Function |
Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyze the conjugation of primary or secondary bile acids, or both. The conjugation increases the detergent properties of bile acids in the intestine, which facilitates lipid and fat-soluble vitamin absorption. In turn, bile acids are deconjugated by bacteria in the intestine and are recycled back to the liver for reconjugation (secondary bile acids). May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids. In vitro, catalyzes the hydrolysis of long- and very long-chain sat
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Peroxisome {ECO:0000250}. Note=Cytoplasmic or/and peroxisomal. {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in liver, kidney, gallbladder, proximal intestine and distal intestine. Weakly expressed in adrenal gland, lung, brain and muscle. {ECO:0000269|PubMed:12810727, ECO:0000269|PubMed:9215542}.
|
| Top Pathways |
Primary bile acid biosynthesis, Peroxisome, Bile secretion, Taurine and hypotaurine metabolism, Biosynthesis of unsaturated fatty acids
|