| Gene Symbol |
GOT1
|
| Entrez Gene |
101865666
|
| Alt Symbol |
cAspAT, cCAT
|
| Species |
Monkey
|
| Gene Type |
protein-coding
|
| Description |
Aspartate aminotransferase, cytoplasmic
|
| Other Description |
Glutamate oxaloacetate transaminase 1|Transaminase A|aspartate aminotransferase, cytoplasmic|cysteine aminotransferase, cytoplasmic|cysteine transaminase, cytoplasmic
|
| Swissprots |
Q4R5L1
|
| Accessions |
Q4R5L1 AB169532 BAE01614 AB171707 BAE88770 XM_005566163 XP_005566220 NM_001284930 NP_001271859
|
| Function |
Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3- mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}.
|
| Top Pathways |
Cysteine and methionine metabolism, 2-Oxocarboxylic acid metabolism, Carbon metabolism, Biosynthesis of amino acids, Alanine, aspartate and glutamate metabolism
|
