| Gene Symbol |
POLR3D
|
| Entrez Gene |
661
|
| Alt Symbol |
BN51T, RPC4, RPC53, TSBN51
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
|
| Other Description |
BN51 (BHK21) temperature sensitivity complementing|DNA-directed RNA polymerase III 47 kDa polypeptide|DNA-directed RNA polymerase III subunit D|DNA-directed RNA polymerase III subunit RPC4|RNA polymerase III 47 kDa subunit|RNA polymerase III subunit C4|RPC53 homolog|temperature sensitive complementation, cell cycle specific, tsBN51
|
| Swissprots |
Q9BPV7 Q9BXB3 Q6FI28 P05423 Q9BPZ1
|
| Accessions |
AAA72377 AAD29429 EAW63689 EAW63690 EAW63691 EAW63692 P05423 AF346574 AAK15371 AK026588 AK125346 AK295725 BAG58566 AY092086 AAM18216 BC000516 BC002603 AAH02603 BC003039 BC004484 AAH04484 BQ006609 BX537545 CR536509 CAG38747 CR541803 CAG46602 HQ447310 ADQ31797 M17754 AAA51838 XM_011544629 XP_011542931 XR_949463 NM_001722 NP_001713
|
| Function |
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus.
|
| Top Pathways |
Cytosolic DNA-sensing pathway, Epstein-Barr virus infection, Purine metabolism, RNA polymerase, Pyrimidine metabolism
|