Gene Symbol | CRYM |
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Entrez Gene | 1428 |
Alt Symbol | DFNA40, THBP |
Species | Human |
Gene Type | protein-coding |
Description | crystallin, mu |
Other Description | NADP-regulated thyroid-hormone binding protein|ketimine reductase mu-crystallin|mu-crystallin homolog|thiomorpholine-carboxylate dehydrogenase |
Swissprots | D5MNX0 Q5HYB7 Q14894 |
Accessions | AAB67600 AAB94938 EAW66862 EAW66863 Q14894 AK290852 BAF83541 AK310424 BC008398 BC018061 AAH18061 BG033512 BI860684 BX648477 CAI46030 DQ892377 ABM83303 DQ895591 ABM86517 L02950 AAC16914 U85772 AAB81564 XM_011545740 XP_011544042 NM_001888 NP_001879 NM_001014444 |
Function | Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors. {ECO:0000269|PubMed:21332720}. |
Subcellular Location | Cytoplasm. |
Tissue Specificity | Expressed in neural tissue, muscle and kidney. |
μ-crystallin CRISPR/Cas9 KO Plasmid (h) - sc-406820 from Santa Cruz Biotechnology
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μ-crystallin HDR Plasmid (h) - sc-406820-HDR from Santa Cruz Biotechnology
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μ-crystallin Double Nickase Plasmid (h) - sc-406820-NIC from Santa Cruz Biotechnology
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μ-crystallin Double Nickase Plasmid (h2) - sc-406820-NIC-2 from Santa Cruz Biotechnology
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μ-crystallin CRISPR Activation Plasmid (h) - sc-406820-ACT from Santa Cruz Biotechnology
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μ-crystallin CRISPR Activation Plasmid (h2) - sc-406820-ACT-2 from Santa Cruz Biotechnology
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μ-crystallin Lentiviral Activation Particles (h) - sc-406820-LAC from Santa Cruz Biotechnology
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μ-crystallin Lentiviral Activation Particles (h2) - sc-406820-LAC-2 from Santa Cruz Biotechnology
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μ-crystallin siRNA (h) - sc-40466 from Santa Cruz Biotechnology
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μ-crystallin shRNA Plasmid (h) - sc-40466-SH from Santa Cruz Biotechnology
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μ-crystallin shRNA (h) Lentiviral Particles - sc-40466-V from Santa Cruz Biotechnology
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mu Crystallin RNAi - H00001428-R02 from Novus Biologicals
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mu Crystallin RNAi - H00001428-R01 from Novus Biologicals
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MISSION® esiRNA - EHU034791 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6618 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6618 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02140 from Sigma-Aldrich
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CRYM siRNA (Human) - CRH1004 from Cohesion Biosciences
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CRYM - MBS8224607 from MyBioSource
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shRNA set against Human CRYM (NM_001888.3) - SHH270093 from Creative biogene
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Human CRYM siRNA - orb261506 from Biorbyt
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CRYM shRNA Plasmid (Human) - CHH1004 from Cohesion Biosciences
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CRYM miRNA 3'UTR clone - MiUTR3H-00556 from Creative biogene
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CRYM miRNA 3'UTR clone - MiUTR3H-00557 from Creative biogene
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