PROK1
| Gene Symbol | PROK1 |
|---|---|
| Entrez Gene | 84432 |
| Alt Symbol | EGVEGF, PK1, PRK1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | prokineticin 1 |
| Other Description | EG-VEGF|black mamba toxin-related protein|endocrine-gland-derived vascular endothelial growth factor|mambakine|prokineticin-1 |
| Swissprots | Q5VWD4 P58294 Q8TC69 |
| Accessions | CAI59103 CAN87427 EAW56449 EAW56450 P58294 AF333024 AAK49918 AY029225 AAK33111 AY358683 AAQ89046 BC025399 AAH25399 BM544315 DQ891570 ABM82496 DQ894763 ABM85689 NM_032414 NP_115790 |
| Function | Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis. {ECO:0000269|PubMed:11259612, ECO:0000269|PubMed:11528470, ECO:0000269|PubMed:15292351, ECO:0000269|PubMed:17289879, ECO:0000269|PubMed:18339712}. |
| Subcellular Location | Secreted. |
| Tissue Specificity | Localizes to glandular epithelium, stroma and vascular epithelial cells of first trimester decidua (at protein level). Up-regulated in first trimester decidua when compared with non-pregnant endometrium. Expressed in the steroidogenic glands, ovary, testis, adrenal and placenta. {ECO:0000269|PubMed:11528470, ECO:0000269|PubMed:15292351, ECO:0000269|PubMed:18339712}. |
Active human Prokineticin 1 full length protein - ab69789 from Abcam
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Human Prokineticin 1 full length protein - ab191727 from Abcam
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Human Prokineticin 1 protein fragment - ab51961 from Abcam
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EG-VEGF/PK1 Recombinant Protein - H00084432-P01 from Novus Biologicals
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Recombinant Human EG-VEGF/PK1 Protein - P4380 from Novus Biologicals
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EG-VEGF/PK1 Protein - NBP1-99173 from Novus Biologicals
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Recombinant Human EG-VEGF/PK1 Protein - NBP1-99614 from Novus Biologicals
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EG-VEGF recombinant protein - GTX65451 from GeneTex
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EG-VEGF recombinant protein - GTX53887 from GeneTex
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EG-VEGF recombinant protein - GTX65450 from GeneTex
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Recombinant Human EG-VEGF/PK1 - 1209-EV-025 from R&D Systems
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Recombinant Human EG-VEGF/PK1, CF - 1209-EV-025/CF from R&D Systems
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EG VEGF Protein (OPPA00601) - OPPA00601 from Aviva Systems Biology
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Recombinant EG-VEGF (OPSD00006) - OPSD00006 from Aviva Systems Biology
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Human EG-VEGF protein (His Tag) - orb138747 from Biorbyt
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Human EG VEGF protein - orb80298 from Biorbyt
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EG-VEGF protein - orb97756 from Biorbyt
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Murine EG-VEGF protein - orb223870 from Biorbyt
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EG-VEGF Blocking Peptide - abx064278 from Abbexa
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PROK1 - H00084432-P01-02 from Acris Antibodies
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PROK1 - P4380 from Acris Antibodies
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Endocrine Gland Vascular Endothelial Growth Factor, Human Recombinant - 228-10359-1 from RayBiotech
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Recombinant Human EG-VEGF / PK1 - 228-10359-2 from RayBiotech
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Recombinant Human EG-VEGF / PK1 - 228-10359-3 from RayBiotech
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Endocrine Gland-derived Vascular Endothelial Growth Factor, EG-VEGF, Human, Recombinant - 28-10117 from ARP American Research Products
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