| Gene Symbol |
IST1
|
| Entrez Gene |
9798
|
| Alt Symbol |
OLC1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
increased sodium tolerance 1 homolog (yeast)
|
| Other Description |
IST1 homolog|overexpressed in lung cancer 1|putative MAPK-activating protein PM28
|
| Swissprots |
A8KAH5 Q9BWN2 Q9BQ81 Q3SYM4 P53990 J3QLU7
|
| Accessions |
CAH05496 CAH05497 CAH05498 EAW59205 EAW59206 EAW59207 EAW59208 EAW59209 P53990 AB097052 BAC77405 AK057902 AK291388 BAF84077 AK293022 BAF85711 AK293040 BAF85729 AK295066 BAG58114 AK297088 BAG59603 AK297336 BAG59792 AK301918 BAG63341 AL355695 BC000116 AAH00116 BC000430 AAH00430 BC004359 AAH04359 BC038350 BC103745 AAI03746 BX364250 D79996 BAA11491 DA332434 DA698420 HQ447682 ADQ32167 NM_001270975 NP_001257904 NM_001270976 NP_001257905 NM_001270977 NP_001257906 NM_001270978 NP_001257907 NM_001270979 NP_001257908 NM_014761 NP_055576
|
| Function |
Proposed to be involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. {ECO:0000269|PubMed:19129479, ECO:0000269|PubMed:19129480}.
|
| Subcellular Location |
Cytoplasmic vesicle {ECO:0000269|PubMed:19129479, ECO:0000269|PubMed:19129480}. Note=Localizes to the midbody of dividing cells.
|