Gene Symbol | MIS18A |
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Entrez Gene | 54069 |
Alt Symbol | B28, C21orf45, C21orf46, FASP1, MIS18alpha, hMis18alpha |
Species | Human |
Gene Type | protein-coding |
Description | MIS18 kinetochore protein A |
Other Description | FAPP1-associated protein 1|MIS18 kinetochore protein homolog A|protein Mis18-alpha |
Swissprots | Q542Z0 B2R562 Q9NYP9 |
Accessions | CAF86614 EAX09881 Q9NYP9 AF231921 AAF72945 AF387845 AAK70498 AK075281 BAC11517 AK312073 BAG35009 AW962893 BC042917 AAH42917 BU567844 BU616573 BU623181 CB959520 HQ448405 ADQ32885 NM_018944 NP_061817 |
Function | Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:17199038}. Chromosome {ECO:0000269|PubMed:17199038}. Chromosome, centromere {ECO:0000269|PubMed:17199038}. Note=Associated with centromeres in interphase cells, from late anaphase to the G1 phase. Not detected on centromeres during earlier phases of mitosis. Associated with chromatin. |
Tissue Specificity | Detected in testis. {ECO:0000269|PubMed:17199038}. |
FASP1 CRISPR/Cas9 KO Plasmid (h) - sc-407315 from Santa Cruz Biotechnology
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FASP1 HDR Plasmid (h) - sc-407315-HDR from Santa Cruz Biotechnology
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FASP1 Double Nickase Plasmid (h) - sc-407315-NIC from Santa Cruz Biotechnology
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FASP1 Double Nickase Plasmid (h2) - sc-407315-NIC-2 from Santa Cruz Biotechnology
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FASP1 CRISPR Activation Plasmid (h) - sc-407315-ACT from Santa Cruz Biotechnology
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FASP1 CRISPR Activation Plasmid (h2) - sc-407315-ACT-2 from Santa Cruz Biotechnology
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FASP1 Lentiviral Activation Particles (h) - sc-407315-LAC from Santa Cruz Biotechnology
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FASP1 Lentiviral Activation Particles (h2) - sc-407315-LAC-2 from Santa Cruz Biotechnology
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FASP1 siRNA (h) - sc-91518 from Santa Cruz Biotechnology
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FASP1 shRNA Plasmid (h) - sc-91518-SH from Santa Cruz Biotechnology
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FASP1 shRNA (h) Lentiviral Particles - sc-91518-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN4769 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4769 from Sigma-Aldrich
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MIS18A siRNA (Human) - CRJ0015 from Cohesion Biosciences
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shRNA set against Human C21orf45(NM_018944.2) - SHG121285 from Creative biogene
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Human MIS18A siRNA - orb270516 from Biorbyt
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MIS18A shRNA Plasmid (Human) - CHJ0015 from Cohesion Biosciences
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MIS18A miRNA 3'UTR clone - MiUTR1H-01342 from Creative biogene
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