| Gene Symbol | Pax6 |
|---|---|
| Entrez Gene | 18508 |
| Alt Symbol | 1500038E17Rik, AEY11, Dey, Gsfaey11, Pax-6, Sey |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | paired box 6 |
| Other Description | Dickie's small eye|oculorhombin|paired box gene 6|paired box protein Pax-6|small eye |
| Swissprots | Q8CEI5 P32117 Q64037 Q921Q8 P70601 Q62222 Q8VDB5 Q3UTV5 P63015 |
| Accessions | CAC00635 CAC80514 CAC80515 CAC80516 CAC80517 CAC80518 CAC80519 CAD87441 EDL27745 EDL27746 EDL27747 EDL27748 EDL27749 P63015 AF443223 AAL38015 AF457141 AAL67742 AF457142 AAL67743 AJ292077 CAC83743 AJ307468 CAC83748 AK028059 BAC25729 AK032616 AK045805 AK047243 AK080416 AK139054 BAE23875 AK140480 AK162553 BAE36966 AY064175 AAL40860 BC011272 AAH11272 BC036957 AAH36957 BC069912 BF466986 CF725212 M77842 AAA40109 X63963 CAA45379 XM_006498913 XP_006498976 XM_006498914 XP_006498977 XM_006498915 XP_006498978 XM_011239354 XP_011237656 NM_001244198 NP_001231127 NM_001244200 NP_001231129 NM_001244201 NP_001231130 NM_001244202 NP_001231131 NM_013627 NP_038655 |
| Function | Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus. |
| Tissue Specificity | Isoform 1 and isoform 3 are the major isoforms among different eye tissues. Isoform 1 and isoform 3 are expressed in the retina and cornea. In the lens epithelium, isoform 1 is relatively abundant, but isoform 3 is barely detectable. {ECO:0000269|PubMed:21084637}. |
| Top Pathways | Maturity onset diabetes of the young, Signaling pathways regulating pluripotency of stem cells |
Pax-6 CRISPR/Cas9 KO Plasmid (m) - sc-422119 from Santa Cruz Biotechnology
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Pax-6 HDR Plasmid (m) - sc-422119-HDR from Santa Cruz Biotechnology
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Pax-6 Double Nickase Plasmid (m) - sc-422119-NIC from Santa Cruz Biotechnology
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Pax-6 Double Nickase Plasmid (m2) - sc-422119-NIC-2 from Santa Cruz Biotechnology
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Pax-6 CRISPR Activation Plasmid (m) - sc-422119-ACT from Santa Cruz Biotechnology
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Pax-6 CRISPR Activation Plasmid (m2) - sc-422119-ACT-2 from Santa Cruz Biotechnology
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Pax-6 Lentiviral Activation Particles (m) - sc-422119-LAC from Santa Cruz Biotechnology
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Pax-6 Lentiviral Activation Particles (m2) - sc-422119-LAC-2 from Santa Cruz Biotechnology
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Pax-6 siRNA (m) - sc-36196 from Santa Cruz Biotechnology
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Pax-6 shRNA Plasmid (m) - sc-36196-SH from Santa Cruz Biotechnology
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Pax-6 shRNA (m) Lentiviral Particles - sc-36196-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU074961 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN38295 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND38295 from Sigma-Aldrich
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PAX6 siRNA (Mouse) - CRM2958 from Cohesion Biosciences
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shRNA set against Mouse PAX6 (NM_013627.5) - SHH371164 from Creative biogene
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Pax-6 CRISPR/Cas9 KO Plasmid (m2) - sc-422119-KO-2 from Santa Cruz Biotechnology
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Pax-6 HDR Plasmid (m2) - sc-422119-HDR-2 from Santa Cruz Biotechnology
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Mouse PAX6 siRNA - orb282434 from Biorbyt
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PAX6 shRNA Plasmid (Mouse) - CHM2958 from Cohesion Biosciences
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