Gene Symbol | ONECUT1 |
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Entrez Gene | 3175 |
Alt Symbol | HNF-6, HNF6, HNF6A |
Species | Human |
Gene Type | protein-coding |
Description | one cut homeobox 1 |
Other Description | hepatocyte nuclear factor 6|hepatocyte nuclear factor 6, alpha|one cut domain family member 1 |
Swissprots | Q9UMR6 B2RTV4 Q9UBC0 Q99744 |
Accessions | AAD02033 CAB50769 EAW77461 Q9UBC0 AA699732 BC140830 AAI40831 BP289459 BX118406 EU532019 ACB30402 U77975 AAB61705 U96173 AAD00826 XM_011521482 XP_011519784 XM_011521483 XP_011519785 XM_011521484 XP_011519786 XM_011521485 XP_011519787 XM_011521486 XP_011519788 XM_011521487 XP_011519789 XR_931800 XR_931801 XR_931802 XR_931803 NM_004498 NP_004489 NR_073510 |
Function | Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription. |
Subcellular Location | Nucleus. |
Tissue Specificity | Highly expressed in liver; lower expression in testis and skin. |
Top Pathways | Maturity onset diabetes of the young, Signaling pathways regulating pluripotency of stem cells |
HNF-6 CRISPR/Cas9 KO Plasmid (h) - sc-401082 from Santa Cruz Biotechnology
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HNF-6 HDR Plasmid (h) - sc-401082-HDR from Santa Cruz Biotechnology
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HNF-6 Double Nickase Plasmid (h) - sc-401082-NIC from Santa Cruz Biotechnology
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HNF-6 Double Nickase Plasmid (h2) - sc-401082-NIC-2 from Santa Cruz Biotechnology
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HNF-6 CRISPR Activation Plasmid (h) - sc-401082-ACT from Santa Cruz Biotechnology
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HNF-6 CRISPR Activation Plasmid (h2) - sc-401082-ACT-2 from Santa Cruz Biotechnology
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HNF-6 Lentiviral Activation Particles (h) - sc-401082-LAC from Santa Cruz Biotechnology
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HNF-6 Lentiviral Activation Particles (h2) - sc-401082-LAC-2 from Santa Cruz Biotechnology
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HNF-6 siRNA (h) - sc-37936 from Santa Cruz Biotechnology
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HNF-6 shRNA Plasmid (h) - sc-37936-SH from Santa Cruz Biotechnology
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HNF-6 shRNA (h) Lentiviral Particles - sc-37936-V from Santa Cruz Biotechnology
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HNF-6/ONECUT1 RNAi - H00003175-R01 from Novus Biologicals
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MISSION® esiRNA - EHU120711 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15730 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15730 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03611 from Sigma-Aldrich
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ONECUT1 siRNA (Human) - CRH2168 from Cohesion Biosciences
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HNF-6 CRISPR/Cas9 KO Plasmid (h2) - sc-401082-KO-2 from Santa Cruz Biotechnology
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HNF-6 HDR Plasmid (h2) - sc-401082-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human Onecut1 (NM_004498.1) - SHH366508 from Creative biogene
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shRNA set against Human ONECUT1(NM_004498.1) - SHR070278 from Creative biogene
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ONECUT1 shRNA Plasmid (Human) - CHH2168 from Cohesion Biosciences
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ONECUT1 miRNA 3'UTR clone - MiUTR1H-07061 from Creative biogene
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