Hip1

Gene Symbol Hip1
Entrez Gene 215114
Alt Symbol 2610109B09Rik, A930014B11Rik, E130315I21Rik, mKIAA4113
Species Mouse
Gene Type protein-coding
Description huntingtin interacting protein 1
Other Description HIP-I|hip1|huntingtin-interacting protein 1|huntingtin-interacting protein I
Swissprots Q571K7 Q8VD75 Q3TLS2
Accessions EDL19363 EDL19364 EDL19365 Q8VD75 AK011828 AK020853 BAB32229 AK049237 AK053860 AK087586 BAC39937 AK147246 AK147269 AK163971 AK166346 BAE38720 AK220182 BAD90367 BC017516 AAH17516 BY309818 CF746398 XM_006504415 XP_006504478 XM_011240878 XP_011239180 XM_011240879 XP_011239181 XR_868560 NM_146001 NP_666113
Function Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors. {ECO:0000250|UniProtKB:O00291, ECO:0000269|PubMed:11577110, ECO:0000269|PubMed:11604514, ECO:0000269|PubMed:12839988, ECO:0000269|PubMed:14998932, ECO:0000269|PubMed:16967501, ECO:0000269|PubMed:17329427}.
Subcellular Location Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Endomembrane system {ECO:0000250}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250}. Note=Shuttles between cytoplasm and nucleus. Nuclear translocation can be induced by AR (By similarity). {ECO:0000250}.
Tissue Specificity Most abundantly expressed in brain. In brain, expressed in cortical tissue, hippocampus, the molecular layer of the cerebellum and olfactory bulb. Also expressed in spinal cord and bone marrow (at protein level). Expressed in reproductive tissues. {ECO:0000269|PubMed:11604514, ECO:0000269|PubMed:12839988, ECO:0000269|PubMed:14998932, ECO:0000269|PubMed:16967501, ECO:0000269|PubMed:9140394}.
Top Pathways Huntington's disease

HIP1 CRISPR/Cas9 KO Plasmid (m) - sc-431994 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

HIP1 HDR Plasmid (m) - sc-431994-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

HIP1 Double Nickase Plasmid (m) - sc-431994-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

HIP1 Double Nickase Plasmid (m2) - sc-431994-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

HIP1 CRISPR Activation Plasmid (m) - sc-431994-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

HIP1 CRISPR Activation Plasmid (m2) - sc-431994-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

HIP1 Lentiviral Activation Particles (m) - sc-431994-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

HIP1 Lentiviral Activation Particles (m2) - sc-431994-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

HIP1 siRNA (m) - sc-41983 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

HIP1 shRNA Plasmid (m) - sc-41983-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

HIP1 shRNA (m) Lentiviral Particles - sc-41983-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

MISSION® esiRNA - EMU046371 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN33240 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND33240 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

HIP1 siRNA (Mouse) - CRN1943 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

HIP1 - MBS8230722 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

shRNA set against Mouse HIP1 (NM_146001.2) - SHH312261 from Creative biogene

Category siRNA
Species Reactivities Mouse

Mouse HIP1 siRNA - orb291418 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

HIP1 shRNA Plasmid (Mouse) - CHN1943 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse
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