Gene Symbol | COL1A2 |
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Entrez Gene | 1278 |
Alt Symbol | OI4 |
Species | Human |
Gene Type | protein-coding |
Description | collagen, type I, alpha 2 |
Other Description | alpha 2(I)-collagen|alpha-2 type I collagen|collagen I, alpha-2 polypeptide|collagen alpha-2(I) chain|collagen of skin, tendon and bone, alpha-2 chain|type I procollagen |
Swissprots | Q9UM83 Q9UEF9 Q15947 P08123 Q16511 Q14038 Q13997 P02464 Q13897 Q15177 Q16480 Q9UMI1 Q14057 Q7Z5S6 Q13998 Q9UEB6 Q9UPH0 Q9UML5 Q9UMM6 |
Accessions | AAA51845 AAA51846 AAA51850 AAA51887 AAA52050 AAA52053 AAA59994 AAA60041 AAA60356 AAB22126 AAB69977 AAB93981 AAS02025 ABM98097 BAA25383 CDL93517 CDM55395 CDM55576 EAW76794 EAW76795 EAW76796 P08123 AA457209 AK223175 AK226074 AK297786 BAG60128 AK300194 BAG61967 AK309504 AL833478 BC042586 AAH42586 BC054498 AAH54498 CF125721 J00114 AAA51996 J03464 AAB59374 L47668 AAB59577 M22816 AAA51844 S41099 AAB22761 S62614 AAB26423 S96821 AAB22020 V00503 CAA23761 X02488 CAA26320 X55525 CAA39142 Y00724 CAA68709 Z74616 CAA98969 NM_000089 NP_000080 |
Function | Type I collagen is a member of group I collagen (fibrillar forming collagen). |
Subcellular Location | Secreted, extracellular space, extracellular matrix {ECO:0000255|PROSITE-ProRule:PRU00793}. |
Tissue Specificity | Forms the fibrils of tendon, ligaments and bones. In bones the fibrils are mineralized with calcium hydroxyapatite. |
Top Pathways | Focal adhesion, ECM-receptor interaction, Amoebiasis, Protein digestion and absorption, PI3K-Akt signaling pathway |
COL1A2 CRISPR/Cas9 KO Plasmid (h) - sc-400598 from Santa Cruz Biotechnology
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COL1A2 HDR Plasmid (h) - sc-400598-HDR from Santa Cruz Biotechnology
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COL1A2 Double Nickase Plasmid (h) - sc-400598-NIC from Santa Cruz Biotechnology
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COL1A2 Double Nickase Plasmid (h2) - sc-400598-NIC-2 from Santa Cruz Biotechnology
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COL1A2 CRISPR Activation Plasmid (h) - sc-400598-ACT from Santa Cruz Biotechnology
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COL1A2 CRISPR Activation Plasmid (h2) - sc-400598-ACT-2 from Santa Cruz Biotechnology
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COL1A2 Lentiviral Activation Particles (h) - sc-400598-LAC from Santa Cruz Biotechnology
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COL1A2 Lentiviral Activation Particles (h2) - sc-400598-LAC-2 from Santa Cruz Biotechnology
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COL1A2 siRNA (h) - sc-72156 from Santa Cruz Biotechnology
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COL1A2 shRNA Plasmid (h) - sc-72156-SH from Santa Cruz Biotechnology
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COL1A2 shRNA (h) Lentiviral Particles - sc-72156-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU131521 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6378 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6378 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06400 from Sigma-Aldrich
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COL1A2 siRNA (Human) - CRH0894 from Cohesion Biosciences
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COL1A2 - MBS8233629 from MyBioSource
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shRNA set against Human COL1A2(NM_000089.3) - SHG189889 from Creative biogene
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COL1A2 CRISPR/Cas9 KO Plasmid (h2) - sc-400598-KO-2 from Santa Cruz Biotechnology
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COL1A2 HDR Plasmid (h2) - sc-400598-HDR-2 from Santa Cruz Biotechnology
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Human CO1A2 siRNA - orb261396 from Biorbyt
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COL1A2 shRNA Plasmid (Human) - CHH0894 from Cohesion Biosciences
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COL1A2 miRNA 3'UTR clone - MiUTR1H-02311 from Creative biogene
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