| Gene Symbol | Aox3 |
|---|---|
| Entrez Gene | 71724 |
| Alt Symbol | 1200011D03Rik, AI326299, Aoh1, Aoh2 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | aldehyde oxidase 3 |
| Other Description | aldehyde oxidase 1|aldehyde oxidase homolog 1|aldehyde oxidase structural homolog 2|azaheterocycle hydroxylase 3 |
| Swissprots | B2RSI5 G3X982 Q8VI15 |
| Accessions | AAL36596 AAQ24539 AAQ24540 EDL00068 EDL00069 G3X982 AF172276 AAD51028 AK004700 BAB23485 AK030109 AK050061 AK054065 BAC35643 AK143048 AK149434 AV275739 AY347569 AAQ24537 AY347570 AAQ24538 BB616838 BC024046 BC049853 BC138876 AAI38877 BX633666 XM_006496284 XP_006496347 XM_006496285 XP_006496348 NM_023617 NP_076106 |
| Function | Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide and phthalazine, as well as aldehydes, such as benzaldehyde, retinal and pyridoxal. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also may catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. {ECO:0000269|PubMed:11562361, ECO:0000269|PubMed:18981221, ECO:0000269|PubMed:21705476, ECO:0000269|PubMed:23019336}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:11562361, ECO:0000269|PubMed:15383531}. |
| Tissue Specificity | Highly expressed in liver (at protein level). In liver, the expression is greater in males than females. {ECO:0000269|PubMed:11562361, ECO:0000269|PubMed:15383531, ECO:0000269|PubMed:18981221}. |
| Top Pathways | Tyrosine metabolism, Vitamin B6 metabolism, Nicotinate and nicotinamide metabolism, Retinol metabolism, Tryptophan metabolism |