CLASP2

Gene Symbol CLASP2
Entrez Gene 23122
Alt Symbol -
Species Human
Gene Type protein-coding
Description cytoplasmic linker associated protein 2
Other Description CLIP-associating protein 2|cytoplasmic linker-associated protein 2|multiple asters (Mast)-like homolog 2|protein Orbit homolog 2
Swissprots Q9NSZ2 B2RTR1 Q9BQT4 Q8N6R6 O75122 Q9H7A3 F5H604 Q7L8F6 Q9BQT3
Accessions EAW64459 EAW64460 EAW64461 EAW64462 EAW64463 EAW64464 EAW64465 EAW64466 EAW64467 O75122 AB014527 BAA31602 AJ288058 CAC35157 AJ288059 CAC35158 AK024770 BAB14995 AK090716 BAG52218 AK091451 BAC03667 AK293963 BAG57335 AK294345 BAG57614 AK297322 BAG59785 AL137636 CAB70852 BC011530 AAH11530 BC029035 AAH29035 BC140778 AAI40779 BX640725 CAE45842 CR626991 DA321422 DQ200868 ABB13628 DQ200869 ABB13629 XM_006713036 XP_006713099 XM_006713040 XP_006713103 XM_006713041 XP_006713104 XM_006713042 XP_006713105 XM_006713048 XP_006713111 XM_006713049 XP_006713112 XM_006713050 XP_006713113 XM_006713052 XP_006713115 XM_006713053 XP_006713116 XM_006713056 XP_006713119 XM_006713057 XP_006713120 XM_006713058 XP_006713121 XM_006713060 XP_006713123 XM_011533505 XP_011531807 XM_011533506 XP_011531808 XM_011533507 XP_011531809 XM_011533508 XP_011531810 XM_011533509 XP_011531811 XM_011533510 XP_011531812 XM_011533511 XP_011531813 XM_011533512 XP_011531814 XM_011533513 XP_011531815 XM_011533514 XP_011531816 XM_011533515 XP_011531817 XM_011533516 XP_011531818 XM_011533517 XP_011531819 XM_011533518 XP_011531820 XM_011533519 XP_011531821 XM_011533520 XP_011531822 XM_011533521 XP_011531823 XM_011533522 XP_011531824 NM_001207044 NP_001193973 NM_015097 NP_055912
Function Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16824950, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514
Subcellular Location Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Golgi apparatus. Golgi apparatus, trans-Golgi network. Cell membrane. Cell projection, ruffle membrane. Note=Localizes to microtubule plus ends. Localizes to centrosomes, kinetochores and the mitotic spindle from prometaphase. Subsequently localizes to the spindle midzone from anaphase and to the midbody from telophase. In migrating cells localizes to the plus ends of microtubules within the cell body and to the entire microtubule lattice within the lamella. Localizes to the cell cortex and this requires ERC1 and PHLDB2. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosophorylated form to the cell membrane.
Tissue Specificity Brain-specific.

CLASP2 CRISPR/Cas9 KO Plasmid (h) - sc-403609 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CLASP2 HDR Plasmid (h) - sc-403609-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CLASP2 Double Nickase Plasmid (h) - sc-403609-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CLASP2 Double Nickase Plasmid (h2) - sc-403609-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CLASP2 CRISPR Activation Plasmid (h) - sc-403609-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CLASP2 CRISPR Activation Plasmid (h2) - sc-403609-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CLASP2 Lentiviral Activation Particles (h) - sc-403609-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CLASP2 Lentiviral Activation Particles (h2) - sc-403609-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CLASP2 siRNA (h) - sc-78538 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CLASP2 shRNA Plasmid (h) - sc-78538-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CLASP2 shRNA (h) Lentiviral Particles - sc-78538-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU100411 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

MISSION® esiRNA - EHU096451 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN6161 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6161 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

CLASP2 siRNA (Human) - CRH8014 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CLASP2 - MBS8214942 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human CLASP2 (NM_015097.2) - SHH264461 from Creative biogene

Category siRNA
Species Reactivities Human

Human CLASP2 siRNA - orb268516 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CLASP2 shRNA Plasmid (Human) - CHH8014 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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