| Gene Symbol |
AGPAT9
|
| Entrez Gene |
84803
|
| Alt Symbol |
AGPAT 10, AGPAT8, GPAT3, HMFN0839, LPAAT-theta, MAG1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
1-acylglycerol-3-phosphate O-acyltransferase 9
|
| Other Description |
1-AGP acyltransferase 9|1-AGPAT 9|1-acyl-sn-glycerol-3-phosphate O-acyltransferase 10|1-acyl-sn-glycerol-3-phosphate O-acyltransferase 9|1-acylglycerol-3-phosphate O-acyltransferase 8|GPAT-3|MAG-1|acyl-CoA:glycerol-3-phosphate acyltransferase 3|endoplasmic reticulum associated GPAT|glycerol-3-phosphate acyltransferase 3|hGPAT3|lung cancer metastasis-associated protein 1|lysophosphatidic acid acyltransferase theta|lysophosphatidic acid acyltransferase, theta
|
| Swissprots |
Q96NA3 Q68CJ4 Q6GPI6 Q53EU6
|
| Accessions |
CAT16202 CBX47664 EAX05944 EAX05945 EAX05946 Q53EU6 AB075872 BAD38654 AK055749 BAB71002 AK223543 BAD97263 AY358100 AAQ88467 BC006236 BC073136 AAH73136 BC090956 AAH90956 BM841009 DA393801 DA673378 DQ324782 ABC55674 DQ345298 ABC70186 XM_011532383 XP_011530685 XM_011532384 XP_011530686 NM_001256421 NP_001243350 NM_001256422 NP_001243351 NM_032717 NP_116106
|
| Function |
May transfer the acyl-group from acyl-coA to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Also transfers the acyl-group from acyl-coA to the sn-2 position of 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid, or LPA), forming 1,2-diacyl-sn-glycerol-3- phosphate (phosphatidic acid, or PA). {ECO:0000269|PubMed:17002884, ECO:0000269|PubMed:17170135, ECO:0000269|PubMed:19318427}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:17002884, ECO:0000269|PubMed:19318427}; Multi- pass membrane protein {ECO:0000269|PubMed:17002884, ECO:0000269|PubMed:19318427}.
|
| Tissue Specificity |
Widely expressed. Expressed in liver, kidney, testis, brain, heart, skeletal muscle, thyroid, prostate, thymus and placenta. Also expressed lung and adipose tissue. {ECO:0000269|PubMed:17002884, ECO:0000269|PubMed:17170135}.
|
| Top Pathways |
Glycerolipid metabolism, Glycerophospholipid metabolism
|