| Gene Symbol |
CRYAA
|
| Entrez Gene |
1409
|
| Alt Symbol |
CRYA1, CTRCT9, HSPB4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
crystallin, alpha A
|
| Other Description |
alpha-crystallin A chain|crystallin, alpha-1|heat shock protein beta-4|human alphaA-crystallin (CRYA1)
|
| Swissprots |
Q53X53 P02489
|
| Accessions |
AAA52105 AAA52106 AAB21309 AAB33370 AAB99912 BAA95535 EAX09497 EAX09498 P02489 BC069528 AAH69528 BC113598 AAI13599 BE552434 BM679139 BX118596 CR407691 CAG28619 HQ258067 ADR82821 HQ448434 ADQ32914 L25781 AAC37570 U05569 AAA97523 U66584 AAC50900 X14789 CAA32891 XM_005261093 XP_005261150 NM_000394 NP_000385
|
| Function |
Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. {ECO:0000269|PubMed:22120592}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:19464326}. Nucleus {ECO:0000269|PubMed:19464326}. Note=Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.
|
| Tissue Specificity |
Expressed in eye lens. {ECO:0000269|PubMed:12356833}.
|
| Top Pathways |
Protein processing in endoplasmic reticulum
|
![Western Blot: alpha A Crystallin Overexpression Lysate (Adult Normal) [NBP2-10665] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for alpha A Crystallin.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2319_alpha%2520A%2520Crystallin%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10665-img0001.jpg)